尿石素C CAS#: 165393-06-6

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尿石素C

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 尿石素C价格(试剂级) 上下游产品信息

中文名称	尿石素C
中文同义词	尿石素C;3,8,9-三羟基-6H-苯并[C]色烯-6-酮
英文名称	Urolithin C
英文同义词	3,8,9-Trihydroxy-6H-benzo[c]chromen-6-one;Urolithin C;3,8,9-Trihydroxy-6H-dibenzo[b,d]pyran-6-one;6H-Dibenzo[b,d]pyran-6-one, 3,8,9-trihydroxy-;Uro-C;insulin,Ca channels,Apoptosis,Polyphenols,ROS,mitochondria,anti-diabetic,gut-microbial,Reactive Oxygen Species,Inhibitor,Endogenous Metabolite,glucose-dependent,metabolite,Calcium Channel,β-cells,Urolithin C,ERK1/2,Ca2+ channels,inhibit;Urolithin C  ( synthetic)
CAS号	165393-06-6
分子式	C13H8O5
分子量	244.2
EINECS号
相关类别	对照品;HR140137
Mol文件	165393-06-6.mol
结构式

尿石素C 性质

尿石素C 用途与合成方法

生物活性

Urolithin C， 是鞣花酸的多酚类肠道微生物代谢产物，是胰岛素分泌 (insulin secretion) 的葡萄糖依赖性激活剂。Urolithin C 是一种 L 型 Ca2+ 通道开放剂，可增强 Ca2+ 的流入。Urolithin C 通过线粒体介导的途径诱导细胞凋亡 (apoptosis)，并刺激活性氧 (ROS) 的形成。

靶点

Insulin secretion  
 L-type Ca     ²⁺    channel  
 Reactive oxygen species (ROS)  
 Apoptosis

体外研究

Urolithin C (20-100 μM; 1 hour; INS-1 cells) treatment enhances glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation in INS-1 β-cells.  
 Urolithin C significantly inhibits the proliferation of PC12 cells. Urolithin C treatment actively increases the lactate dehydrogenase (LDH) release and lipid peroxidation malondialdehyde (MDA), stimulates reactive oxygen species (ROS) formation and mitochondrial membrane depolarization, and caused calcium dyshomeostasis.  
 Urolithin C treatment induces apoptosis and S phase cell cycle arrest.

Western Blot Analysis

体内研究

The pharmacokinetics of Urolithin C (10 mg/kg; intraperitoneal administration) in male Wistar rat (140-160 g) are studied. The half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V     ₁    /F) and the steady-state volume of distribution (Vss/F) are 0.831 L/kg and 55.6 L/kg, respectively.

安全信息

MSDS信息

尿石素C 价格(试剂级)

尿石素C 上下游产品信息