贝托斯汀 CAS#: 125602-71-3

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贝托斯汀

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 贝托斯汀价格(试剂级) 上下游产品信息

中文名称	贝托斯汀
中文同义词	贝托斯汀;贝托司汀;4-[4-[(4-氯苯基)吡啶-2-基甲氧基]哌啶-1-基]丁酸;(+)-BEPOTASTINE;BEPOTASTINE >90%;苯钾碱;(S)-4-(4-((4-氯苯基)(吡啶-2-基)甲氧基)哌啶-1-基)丁酸;S)-贝托斯汀
英文名称	BEPOTASTINE
英文同义词	4-(4-[(1S)(4-CHLOROPHENYL)-2-PYRIDYLMETHOXY]PIPERIDYL)BUTANOIC ACID;1-Piperidinebutanoic acid, 4-[(S)-(4-chlorophenyl)-2-pyridinylmethoxy]-;betotastine besilate;4-[4-[(4-Chlorophenyl)pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid;(+)-(S)-4-[4-[1-(4-chlorophenyl)-1-(2-pyridyl)methoxy]piperidin-1-yl]butyric acid;4-[(S)-(4-chlorophenyl)-2-pyridinylMethoxy]-;-4-(4-((4-Chlorophenyl);BEPOTASTINE
CAS号	125602-71-3
分子式	C21H25ClN2O3
分子量	388.89
EINECS号	200-258-5
相关类别	医药原料药;原料药;原料药及中间体
Mol文件	125602-71-3.mol
结构式

贝托斯汀 性质

贝托斯汀 用途与合成方法

生物活性

Bepotastine是一种非镇静的、选择性histamine 1 (H1) receptor拮抗剂。

靶点

Histamine H1 receptor

体外研究

Bepotastine possesses additional anti-allergic activity including stabilization of mast cell function, inhibition of eosinophilic infiltration, inhibition of IL-5 production, and inhibition of leukotriene B4 (LTB4) and LTD4 activity.  
 Bepotastine significantly inhibits antigen-induced stimulation of IL-5 production in human peripheral blood mononuclear cells (PBMCs) at concentrations of 10-100 μM and the effect is enhanced when the PBMCs are pre-incubated with Bepotastine.  
 Leukotriene B4 increased Ca2+ concentration in cultured neutrophils, which is suppressed by Bepotastine besilate (1-100 μM). Leukotriene B4 increased Ca2+ concentration in cultured dorsal root ganglion neurons, which is also suppressed by Bepotastine besilate (100 μM).

体内研究

Bepotastine besilate (10 mg/kg) inhibits scratching induced by an intradermal injection of histamine (100 nmol/site), but not serotonin (100 nmol/site).  
 Bepotastine besilate (1-10 mg/kg, oral) dose-dependently suppresses scratching induced by substance P (100 nmol/site) and leukotriene B4 (0.03 nmol/site). Bepotastine in vivo dose-dependently inhibits the acceleration of histamine-induced vascular permeability and inhibits homologous passive cutaneous anaphylaxis in guinea pig studies.  
 In mouse models of itching, oral Bepotastine inhibits the frequency and duration of scratching behavior.

安全信息

MSDS信息

贝托斯汀 价格(试剂级)

贝托斯汀 上下游产品信息