1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE CAS#: 303149-14-6

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1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE价格(试剂级) 上下游产品信息

中文名称	1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE
中文同义词	化合物HT-2157
英文名称	HT-2157
英文同义词	HT-2157;SNAP 37889;1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE;SNAP 37889, CID1471834;HT-2157(SNAP37889);1-phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one;2H-Indol-2-one, 1,3-dihydro-1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-;SNAP-37889 (HT-2157)
CAS号	303149-14-6
分子式	C21H13F3N2O
分子量	366.34
EINECS号
相关类别
Mol文件	303149-14-6.mol
结构式

1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE 性质

1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE 用途与合成方法

生物活性

HT-2157(SNAP 37889) 是一种选择性的高亲和力甘丙肽-3 受体 (Gal3) 竞争性拮抗剂。

靶点

Galanin-3 receptor

体外研究

HT-2157 (SNAP 37889) binds with high affinity to membranes from transiently transfected LMTK     ^-    cells expressing the human Gal     ₃    receptor (K     _i    =17.44±0.01 nM; n>100) and is highly selective for Gal     ₃    over the Gal     ₁    and Gal     ₂    subtypes (K     _i    >10,000 nM for each subtype; n=46 of each subtype). When tested for the antagonism of galanin-evoked inhibition of adenylyl cyclase, HT-2157 (0.1-10 μM) produces concentration-dependent rightward shifts of the concentration-effect curve to galanin.

体内研究

The galanin-3 receptor antagonist, HT-2157 (SNAP 37889), reduces operant responding for ethanol in alcohol-preferring rats. The novel selective GALR3 antagonist, HT-2157, to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat. Male iP rats treated with HT-2157 at a dose of 30 mg/kg (i.p.) do not show altered locomotor activity or changes in anxiety-like behaviour in the elevated plus maze or light-dark paradigms. Treatment with HT-2157 (30 mg/kg, i.p.) reduces operant responding for solutions containing ethanol, sucrose and saccharin. Collectively, results from the current study shows that HT-2157 (30 mg/kg, i.p.) is effective in reducing operant responding for ethanol, independent of a sedative effect.

安全信息

MSDS信息

1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE 价格(试剂级)

1-PHENYL-3-[[3-(TRIFLUOROMETHYL)PHENYL]IMINO]-1H-INDOL-2-ONE 上下游产品信息

上游原料

1-苯基靛红间氨基三氟甲苯