218137-86-1 CAS#: 218137-86-1

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218137-86-1

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 218137-86-1价格(试剂级) 上下游产品信息

中文名称	218137-86-1
中文同义词	化合物 T10657;化合物C75
英文名称	3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
英文同义词	3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE;C75;C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid);TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE;TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID;FAS inhibitor C75 (C-75;3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-;C75 >=98% (HPLC), powder
CAS号	218137-86-1
分子式	C14H22O4
分子量	254.32
EINECS号
相关类别
Mol文件	218137-86-1.mol
结构式

218137-86-1 性质

218137-86-1 用途与合成方法

生物活性

C75 是合成的脂肪酸合成酶 (FASN) 抑制剂。C75 抑制前列腺癌细胞 PC3 的 IC50 值为 35 μM。C75 是有效的 CPT1A 激活剂。

靶点

IC50: 35 μM (PC3 cell)

体外研究

C75 inhibits PC3 cell growht with an IC     ₅₀    of 35 μM at 24 h. C75 (10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC     ₅₀    of 50 μM. (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity.

体内研究

C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA.

安全信息

MSDS信息

218137-86-1 价格(试剂级)

218137-86-1 上下游产品信息