HOECHST 34580 CAS#: 23555-00-2

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HOECHST 34580

生物活性靶点体外研究 用途与合成方法 MSDS HOECHST 34580价格(试剂级) 上下游产品信息

中文名称	HOECHST 34580
中文同义词	赫斯特34580游离;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-联苯并[D]咪唑]-2'-基)苯胺;化合物HOECHST 34580;NO34580 荧光染料;N,N-二甲基-4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-联苯并[D]咪唑]-2'-基)苯胺
英文名称	HOECHST 34580
英文同义词	HOECHST 34580;HOE 34580;ProaMine;2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-;Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-;Hoechst 34580 (HOE 34580);N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline;N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)aniline
CAS号	23555-00-2
分子式	C27H29N7
分子量	451.57
EINECS号
相关类别	Benzimidazole
Mol文件	23555-00-2.mol
结构式

HOECHST 34580 性质

HOECHST 34580 用途与合成方法

生物活性

Hoechst 34580 (HOE 34580) 是一种具有细胞渗透性的蓝色荧光染料，用于染色DNA和细胞核。Hoechst 34580 也是一种治疗阿尔茨海默病的良好候选者，通过抑制 amyloid beta (Aβ) 的形成，其IC50值为0.86 μM。

靶点

体外研究

Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC     ₅₀    of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC     ₅₀    ) is examined. The IC     ₅₀    is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580.

安全信息

MSDS信息

HOECHST 34580 价格(试剂级)

HOECHST 34580 上下游产品信息