S-腺苷甲硫氨酸对甲苯磺酸盐 CAS#: 71914-80-2

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S-腺苷甲硫氨酸对甲苯磺酸盐

生物活性体外研究体内研究 用途与合成方法 MSDS S-腺苷甲硫氨酸对甲苯磺酸盐价格(试剂级) 上下游产品信息

中文名称	S-腺苷甲硫氨酸对甲苯磺酸盐
中文同义词	S-腺甙甲硫氨酸对甲苯磺酸盐;S-腺苷甲硫氨酸对甲苯磺酸盐;S-腺苷甲硫氨酸对甲苯磺酸盐(S-腺甙甲硫氨酸对甲苯磺酸盐);S-腺苷甲硫氨酸对甲苯磺酸盐 17176-17-9/;腺苷蛋氨酸甲苯磺酸盐;S-腺苷-L-蛋氨酸甲磺酸盐;S-腺苷-L-甲硫氨酸(苯磺酸盐)
英文名称	S-Adenosyl-L-methionine tosylate
英文同义词	S-ADENOSYLMETHIONINE TOSYLATE;S-Adenosyl-L-methionine tosylate;S-(5'-ADENOSYL)-L-METHIONINE P-TOLUENESULFONATE;S-(5'-ADENOSYL)-L-METHIONINE TOLUENE-4-SULFONATE;SAM-E;S-(5'-ADENOSYL)-L-METHIONINETOLUENE-   &;S-ADENOSYL-L-METHIONINE (SAME);S-(5''-Adenosyl)-L-methionine-4-toluenesulfonate
CAS号	71914-80-2
分子式	C15H23N6O5S.C7H7O3S
分子量	570.64
EINECS号
相关类别	医药原料;化学试剂;医用原料
Mol文件	71914-80-2.mol
结构式

S-腺苷甲硫氨酸对甲苯磺酸盐 性质

S-腺苷甲硫氨酸对甲苯磺酸盐 用途与合成方法

生物活性

S-Adenosyl-L-methionine tosylate (S-Adenosyl methionine tosylate) 是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的，是一种重要的具有口服活性的甲基供体。S-Adenosyl-L-methionine tosylate 是一种具有有效的抗抑郁和镇痛作用的膳食补充剂，并可用于肝病和骨关节炎的研究。

体外研究

S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) and then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine and the sulfate (SO4) donated to other metabolic intermediates; and 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form and recycle methionine.  
 In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis and proliferation rates in rabbits.

体内研究

Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC.

安全信息

MSDS信息

S-腺苷甲硫氨酸对甲苯磺酸盐 价格(试剂级)

S-腺苷甲硫氨酸对甲苯磺酸盐 上下游产品信息