环芬尼 CAS#: 2624-43-3

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环芬尼

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 环芬尼价格(试剂级) 上下游产品信息

中文名称	环芬尼
中文同义词	环芬尼;双醋环烷;环己基亚甲基二苯酚二乙酸酯;双氯胍
英文名称	Cyclofenil
英文同义词	4-((4-(acetyloxy)phenyl)cyclohexylidenemethyl)-phenoacetate;alpha-cyclohexylidene-alpha-(p-hydroxyphenyl)-p-cresodiacetate;bis-(p-acetoxyphenyl)-cyclohexylidenemethane;bis-(p-hydroxyphenyl)-cyclohexylidenemethanediacetate;cyclofenyl;cyclophenil;cyclophenyl;f6066
CAS号	2624-43-3
分子式	C23H24O4
分子量	364.44
EINECS号	220-089-1
相关类别	合成;化工原料;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件	2624-43-3.mol
结构式

环芬尼 性质

环芬尼 用途与合成方法

生物活性

Cyclofenil 是一种选择性雌激素受体 (estrogen receptor) 调节剂和排卵诱导剂。Cyclofenil 对 Vero 细胞中的登革热病毒复制具有抑制作用，EC50 为 1.62 μM。 Cyclofenil 具有抗登革热病毒的活性。

靶点

体外研究

Cyclofenil shows an inhibitory effect on dengue virus (DENV) replication in mammalian cells but not in mosquito cells.  
 Cyclofenil also inhibits the replication of Zika virus. A time-of-addition assay suggested that Cyclofenil may interfere with two stages of the Dengue virus (DENV) life cycle: the translation-RNA synthesis and assembly-maturation stages. The level of intracellular infectious particles decreased more drastically after treatment with Cyclofenil than the viral RNA level do, indicating that the assembly-maturation stage might be the main target of Cyclofenil.

体内研究

The number of estrogen receptors α (ERα) and β (ERβ)-immunoreactive (-ir) cells is determined of each stage of the estrous cycle in intact rats. Additionally, the effects of blocking ERα and ERβ on ovulation rate on diestrus-2 or proestrus day through the microinjection of methyl-piperidino-pyrazole (MPP) or Cyclofenil in either side of preoptic-anterior hypothalamic area (POA-AHA) are evaluated. The number of ERα-ir and ERβ-ir cells in POA-AHA varied in each phase of estrous cycle. Either MPP or Cyclofenil in the right side of POA-AHA on diestrus-2 day reduced the ovulation rate, while at proestrus day it was decreased in rats treated in either side with MPP, and in those treated with Cyclofenil in the left side. MPP or Cyclofenil produced a decrease in the surge of luteinizing hormone levels (LH) and an increase in progesterone and follicle stimulating hormone (FSH).

安全信息

MSDS信息

环芬尼 价格(试剂级)

环芬尼 上下游产品信息

上游原料

镁氯化铵氢氧化钾乙酐4-溴苯甲醚