L-2,4-二氨基丁酸氢溴酸盐 CAS#: 1758-80-1

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L-2,4-二氨基丁酸氢溴酸盐

生物活性靶点体外研究体内研究 用途与合成方法 MSDS L-2,4-二氨基丁酸氢溴酸盐价格(试剂级) 上下游产品信息

中文名称	L-2,4-二氨基丁酸氢溴酸盐
中文同义词	L-2,4-二氨基丁酸氢溴酸盐;L-2,4-二氨基丁酸;L-2,4-二氨基丁酸氨溴酸盐;L-2,4-二氨基丁酸氢溴酸盐· HCL
英文名称	L-DAB HBR
英文同义词	L-2,4-DIAMINOBUTYRIC ACID HYDROBROMIDE;L-DAB HBR;L-DAB HYDROBROMIDE;L-2,4-Diaminobutanoate;H-DabHBr;(S)-2,4-Diaminobutyric acid;L-DABA;(S)-2,4-diaminobutanoic acid
CAS号	1758-80-1
分子式	C4H10N2O2
分子量	118.13
EINECS号
相关类别	非天然氨基酸极其衍生物;化学生物学;其他生化试剂;Unusual Amino Acids;Amino  hydrochloride
Mol文件	1758-80-1.mol
结构式

L-2,4-二氨基丁酸氢溴酸盐 性质

L-2,4-二氨基丁酸氢溴酸盐 用途与合成方法

生物活性

L-DABA (L-2,4-Diaminobutyric acid)是GABA转氨酶的弱抑制剂，IC50 值大于500 μM。在体内和体外具有抗肿瘤活性。

靶点

体外研究

The tumor cells are irreversibly and totally damaged by incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C. The cell-destructive effect by L-DABA is probably due to an osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA. The harmful effect of L-DABA could be abolished by concomitant incubation with L-alanine and L-methionine. Kinetic studies indicates that L-DABA is a non-linear, non-competitive inhibitor of GABA transaminase activity. The L-DABA-induced elevation of GABA levels parallels the inhibition of GABA transaminase activity. L-2,4-Diaminobutyric acid, an amino acid analogue, produceS a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line.

体内研究

Treatment with L-DABA results in 43.4% reduction of tumor growth. L-DABA is a more effective inhibitor of GABA transaminase     in vivo    than     in vitro    .

安全信息

MSDS信息

L-2,4-二氨基丁酸氢溴酸盐 价格(试剂级)

L-2,4-二氨基丁酸氢溴酸盐 上下游产品信息