AM2394 CAS#: 1442684-77-6

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AM2394

用途生物活性靶点体内研究 用途与合成方法 MSDS AM2394价格(试剂级) 上下游产品信息

中文名称	AM2394
中文同义词	化合物AM2394;AM-2394游离态;1-(6'-(2-羟基-2-甲基丙氧基)-4-((5-甲基吡啶-3-基)氧基)-[3,3'-联吡啶]-6-基)-3-甲基脲;AM 2394,葡萄糖激酶激活剂;1-(6'-(2-羟基-2-甲基丙氧基)-4-((5-甲基吡啶-3-基)氧基)-[3,3'-联吡啶]-6-基)-3-甲基脲
英文名称	AM2394
英文同义词	AM2394;1-(6'-(2-hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea;AM2394;AM 2394;CS-2242;N-[6'-(2-Hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methylurea;Urea, N-[6'-(2-hydroxy-2-methylpropoxy)-4-[(5-methyl-3-pyridinyl)oxy][3,3'-bipyridin]-6-yl]-N'-methyl-;AM-2394,Hexokinase D,Inhibitor,AM 2394,Glucokinase,inhibit,Hexokinase IV;1-(6'-(2-Hydroxy-2-methylpropoxy)-4-((5-methylpyridin-3-yl)oxy)-[3,3'-bipyridin]-6-yl)-3-methylurea
CAS号	1442684-77-6
分子式	C22H25N5O4
分子量	423.46
EINECS号
相关类别	抑制剂;API
Mol文件	1442684-77-6.mol
结构式

AM2394 性质

AM2394 用途与合成方法

用途

AM 2394是一种结构独特的葡萄糖激酶激活剂(GKA)。AM-2394通过一个60 nM的EC50激活GK。

生物活性

AM-2394 是一种新型的 glucokinase 激活剂 (GKA)。AM-2394激活葡萄糖激酶 (GK)，EC50 为 60 nM。

靶点

EC50: 60 nM (glucokinase)

体内研究

AM-2394, a structurally distinct glucokinase activator that displays a robust reduction in plasma glucose during an oral glucose tolerance test (OGTT) in     ob/ob    mice at a dose of 3 mg/kg. AM-2394 increases the affinity of glucokinase (GK) for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an     ob/ob    mouse model of diabetes. AM-2394 exhibits good-to-moderate cross species plasma clearance, volume of distribution, and oral bioavailability, allowing for further evaluation in animal models.

安全信息

MSDS信息

AM2394 价格(试剂级)

AM2394 上下游产品信息