1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochlo

微信扫码

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride

生物活性靶点体内研究 用途与合成方法 MSDS 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride价格(试剂级) 上下游产品信息

中文名称	1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
中文同义词	盐酸左卡巴司丁;3-(3,4-二羟基苯基)-L-丙氨酸;3-羟基酪氨酸;L-Β-(3,4-二羟基苯基)初油氨基酸;L-Β-3,4-二羟基苯丙氨酸;左卡巴斯汀盐酸盐;左卡巴斯汀,用于系统适应性1 EP标准品;盐酸左卡巴斯汀 EP标准品
英文名称	1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
英文同义词	R50547;LIVOSTIN;[3s-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid;4-Piperidinecarboxylic acid, 1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, [3S-[1(cis),3a,4b]]-;4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, monohydrochloride, (3S,4R)- (9CI);Levophta,  Levostin,  R50547,  [3S-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic  acid;LEVOPHTA;LEVOCABASTINE HCL
CAS号	79547-78-7
分子式	C26H30ClFN2O2
分子量	456.99
EINECS号	209-062-5
相关类别	医药原料;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件	79547-78-7.mol
结构式

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 性质

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 用途与合成方法

生物活性

Levocabastine hydrochloride (R 50547) 是一种具有抗过敏活性的长效、高效、选择性组胺 H1 受体拮抗剂。Levocabastine hydrochloride 也是一种选择性、高亲和力的神经降压素受体亚型2 (NTR2) 拮抗剂，对 mNTR2 的 Ki 值为 17 nM。

靶点

体内研究

Levocabastine (0.25 mg/kg; i.p.; twice a day for five successive days; guinea-pigs) inhibits the virus-induced airway hyperresponsiveness, suppresses the influx of broncho-alveolar cells and increase in albumin content, and corrects the reduced chemiluminescence production by broncho-alveolar cells in response to zymosan.  
 In mice that receivedβ-LT, Levocabastine (0.05 mg/kg; i.p.) blocks the anxiolytic effect of β-LT and the number of head-dips decreased.

安全信息

MSDS信息

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 价格(试剂级)

1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride 上下游产品信息

上游原料

丙烯酸乙酯甲醇钠对氟苯乙腈