美托拉宗 CAS#: 17560-51-9

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美托拉宗

生物活性体外研究 用途与合成方法 MSDS 美托拉宗价格(试剂级) 上下游产品信息

中文名称	美托拉宗
中文同义词	7-氯-1,2,3,4-四氢-2-甲基-3-(2-甲基苯基)-4-氧代-6-喹唑磺酰胺;美托拉宗;美托拉宗(标准品);米托拉腙;甲醋唑胺;美托拉腙;美托拉宗杂质;美托拉索 EP标准品
英文名称	Metolazone
英文同义词	s720-22;Zaroxolyn;7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, SR-720-22, Diulo, Metenix, Mykrox, Oldren,;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- (9CI);6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- (8CI);Normelan;Xuret;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro- 2-methyl-3-(2-methylphenyl)-4-oxo-
CAS号	17560-51-9
分子式	C16H16ClN3O3S
分子量	365.83
EINECS号	241-539-3
相关类别	中间体;小分子抑制剂;科研试剂;利尿药物;原料;医药原料;有机化工原料;ZAROXOLYN;Other APIs;Organics;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles;Sulfur & Selenium Compounds
Mol文件	17560-51-9.mol
结构式

美托拉宗 性质

美托拉宗 用途与合成方法

生物活性

Metolazone (SR 720-22)是一种利尿剂，主要用于治疗充血性心脏衰竭和高血压。

体外研究

Metolazone (SR-720-22) is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities.Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. As a result, water remains in the lumen and is excreted as urine, instead of being reabsorbed into the bloodstream. Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule, thiazide diuretics have limited effects on water balance and on electrolyte levels. Nevertheless, they can be associated with low sodium levels, volume depletion, and low blood pressure, among other adverse effects.

用途 

利尿药。

安全信息

MSDS信息

美托拉宗 价格(试剂级)

美托拉宗 上下游产品信息

上游原料

三氯化磷