硝酸毛果芸香碱 CAS#: 148-72-1

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硝酸毛果芸香碱

简介禁忌症生物活性靶点体外研究体内研究 用途与合成方法 MSDS 硝酸毛果芸香碱价格(试剂级) 上下游产品信息 专题

中文名称	硝酸毛果芸香碱
中文同义词	(3S,4R)-3-乙基二氢-4-[(1-甲基-1H-咪唑-5-基)甲基]-2(3H)-呋喃酮硝酸盐;硝酸异毛果芸香碱;硝酸匹鲁卡品(硝酸毛果芸香碱);毛果芸香碱硝酸盐;硝酸匹鲁卡品;硝酸毛果芸香碱杂质Ⅰ( 硝酸异毛果芸香碱)（3R，4R）-3-乙基-4-[（1-甲基-1H-咪唑-5-基）甲基]二氢呋喃-2（3H）-酮，硝酸盐;硝酸毛果芸香碱杂质Ⅰ( 硝酸异毛果芸香碱)(3R,4R)-3-乙基-4-[(1-甲基-1H-咪唑-5-基)甲基]二氢呋喃-2(3H)-酮,硝酸盐;匹鲁卡品硝酸盐
英文名称	Pilocarpine nitrate
英文同义词	3-ETHYLDIHYDRO-4-[(1-METHYL-1H-IMIDAZOL-5-YL)-METHYL]-2-(3H)-FURANONE NITRATE;2(3H)-Furanone, 3-ethyldihydro-4-(1-methyl-1H-imidazol-5-yl)methyl-, (3S,4R)-, mononitrate;PILOCARPINENITRATE,CRYSTAL,USP;Pilagan;Pilocarpinnitrat;(3S)-3-Ethyl-4-[(3-methylimidazol-4-yl)methyl]oxolan-2-one nitrate;(3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone mononitrate;Pilocarpini  nitras
CAS号	148-72-1
分子式	C11H17N3O5
分子量	271.27
EINECS号	205-723-7
相关类别	标准品;对照品;中药对照品;小分子抑制剂;小分子抑制剂，天然产物;原料;Inhibitors;AgonistsDrugs  of  Abuse;Chemical  Structure;Cholinergics;Neurotransmitters;Others;Alkaloids;Alkaloids (Others);Biochemistry;API
Mol文件	148-72-1.mol
结构式

硝酸毛果芸香碱 性质

硝酸毛果芸香碱 用途与合成方法

简介

硝酸毛果芸香碱呈无色结晶或白色结晶性粉末；无臭；遇光易变质。其可用于青光眼、虹膜炎的治疗。

禁忌症

1．对本药过敏者。

2．支气管哮喘患者。

3．急性虹膜炎、虹膜睫状体炎等不应缩瞳的眼病患者。

生物活性

Pilocarpine nitrate 是一种选择性的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。

靶点

M3 muscarinic receptor

体外研究

To evaluate the cytotoxicity of Pilocarpine, the morphology and viability of human corneal stromal (HCS) cells are examined by light microscopy and MTT assay, respectively. Morphological observations show that HCS cells exposed to Pilocarpine at a concentration from 0.625 to 20 g/L exhibit dose- and time-dependent proliferation retardation and morphological abnormality such as cellular shrinkage, cytoplasmic vacuolation, detachment from culture matrix, and eventually death, while no obvious difference is observed between those exposed to Pilocarpine below the concentration of 0.625 g/L and controls. Results of MTT assay reveal that the cell viability of HCS cells decrease with time and concentration after exposing to Pilocarpine above the concentration of 0.625 g/L (P<0.01 or 0.05), while that of HCS cells treated with Pilocarpine below the concentration of 0.625 g/L show no significant difference to controls. The partial muscarinic agonist, Pilocarpine, evokes concentration-dependent relaxation with an EC     ₅₀    of 2.4 mM in isolated segments of rat tail artery that were constricted with Penylephrine (10 to 200 nM).

体内研究

The Pilocarpine-induced saliva secretion of the control rats (CN) and exercised (EX) rats is examined. A significantly greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). Conversely, the Na  ⁺    concentration in the saliva of the EX rats is significantly lower than that of the CN rats (P<0.05).

生产方法 

可由植物毛果芸香提取毛果芸香碱后，再用硝酸处理而制得。

安全信息

MSDS信息

硝酸毛果芸香碱 化学药品说明书

硝酸毛果芸香碱|药典2005版硝酸毛果芸香碱滴眼液|药典2005版

硝酸毛果芸香碱 价格(试剂级)

硝酸毛果芸香碱 上下游产品信息

上游原料

毛果芸香碱硝酸