维生素E醋酸酯 CAS#: 58-60-6

微信扫码

维生素E醋酸酯

生物活性体外研究体内研究 用途与合成方法 MSDS 维生素E醋酸酯价格(试剂级) 上下游产品信息

中文名称	维生素E醋酸酯
中文同义词	氨基甘嘌呤霉素;嘌呤霉素氨基核苷;博罗霉素氨基核苷;氨基核酸嘌呤酶素;氨基核苷嘌呤霉素;3'-氨基-3'-脱氧-N,N-二甲基腺苷;(2R,3R,4S,5S)-4-氨基-2-(6-(二甲基氨基)-9H-嘌呤-9-基)-5-(羟甲基)四氢呋喃-3-醇;PUROMYCIN AMINONUCLEOSIDE 氨基核苷嘌呤霉素 NSC 3056
英文名称	PUROMYCIN AMINONUCLEOSIDE
英文同义词	3’-amino-3’-deoxy-n,n-dimethyl-adenosin;6-(dimethylamino)-9-(3-amino-3-deoxy-beta-d-ribofuranosyl)purine;9-(3-amino-3-deoxy-beta-d-ribofuranosyl)-6-(dimethylamino)-9h-purine;aminonucleoside;aminonucleosidepuromycin;stylomycinaminonucleoside;PUROMYCIN AMINONUCLEOSIDE;6-DIMETHYLAMIN-9-[3'-AMINO-3'DEOXYRIBOSYL]-PURINE
CAS号	58-60-6
分子式	C12H18N6O3
分子量	294.31
EINECS号	200-388-3
相关类别	微生物代谢物;抗生素;生化试剂;医药原料
Mol文件	58-60-6.mol
结构式

维生素E醋酸酯 性质

维生素E醋酸酯 用途与合成方法

生物活性

Puromycin aminonucleoside (NSC 3056)  是一种氨基核苷类抗生素，为嘌呤霉素类似物。Puromycin aminonucleoside 诱导细胞凋亡 (apoptosis)。Puromycin aminonucleoside 可逆抑制二肽基肽酶 (dipeptidyl peptidase II) 和胞浆丙氨酸氨基肽酶。嘌呤霉素氨基核苷是抗生素嘌呤霉素的氨基核苷部分。

体外研究

Puromycin aminonucleoside (NSC 3056) (30 μg/mL) markedly increases p53 protein levels in podocytes. Puromycin aminonucleoside (NSC 3056)-induced podocyte apoptosis is p53 dependent. Puromycin aminonucleoside (NSC 3056) induces podocyte apoptosis in a time-dependent manner. The IC     ₅₀    values for PMAT-expressing and vector-transfected cells are 48.9 and 122.1 μM, respectively, suggesting expression of PMAT-enhanced cell sensitivity to Puromycin aminonucleoside. Puromycin aminonucleoside (NSC 3056) (250 μM) is toxic to both PMAT-expressing and vector-transfected cells. Puromycin aminonucleoside (NSC 3056) uptake in PMAT-expressing cells is fourfold higher at pH 6.6 than that at pH 7.4.

体内研究

The number of podocytes per glomerulus is 95.5±17.6 in the control rats, 90.7 on Day 4 in Puromycin aminonucleoside (NSC 3056) (8 mg/100 g, i.v.)-treated nephrosis rats. The amount of nephrin per glomerulus in control rats is 1.02±0.11 fmol and those in Puromycin aminonucleoside (NSC 3056) nephrosis rats are reduced to 0.46±0.06 fmol and 0.35±0.04 fmol on Day 4 and Day 7. The nephrin amount per podocyte is significantly decreased association with the development of proteinuria in Puromycin aminonucleoside (NSC 3056) nephrosis rats. Rats given Puromycin aminonucleoside (NSC 3056) (100 mg/kg, s.c.) gain less weight and their serum creatinine levels are higher than the control rats.

类别

有毒物品

可燃性危险特性

可燃;燃烧产生有毒氮氧化物烟雾

储运特性

库房通风低温干燥

灭火剂

干粉、泡沫、砂土, 二氧化碳, 雾状水

安全信息

MSDS信息

维生素E醋酸酯 价格(试剂级)

维生素E醋酸酯 上下游产品信息

上游原料

3'-Azido-3'-deoxy-N6,N6-dimethyladenosine