醋酸阿肽地尔 CAS#: 40077-57-4

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醋酸阿肽地尔

概述应用生物活性靶点体外研究体内研究 用途与合成方法 MSDS 醋酸阿肽地尔价格(试剂级) 上下游产品信息 专题

中文名称	醋酸阿肽地尔
中文同义词	血管活性肠肽;血管活性肠肽(抗体);醋酸阿肽地尔;阿肽地尔;血管活性肠肽(VIP)检测试剂盒( ELISA 方法);阿肽地尔, ≥95% (HPLC);AVIPTADIL ACETATE 阿肽地尔;醋酸阿肽地尔 40077-57-4
英文名称	Aviptadil
英文同义词	VASOACTIVE INTESTINAL PEPTIDE (HUMAN, BOVINE, PORCINE, RAT);VASOACTIVE INTESTINAL PEPTIDE (HUMAN, PORCINE);VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, AND RAT;VASOACTIVE INTESTINAL PEPTIDE (HUMAN, PORCINE) (BOVINE, RAT, CANINE);VASOACTIVE INTESTINAL PEPTIDE HUMAN, PORCINE, RAT;VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE;VASOACTIVE INTESTINAL PEPTIDE, PORCINE;VASOACTIVE INTESTINAL PEPTIDE
CAS号	40077-57-4
分子式	C147H238N44O42S
分子量	3325.8
EINECS号	200-001-8
相关类别	多肽类;生化试剂;蛋白质/多肽;医药原料;多肽原料药;医药原料药;多肽;ELISA试剂盒;多肽-客户肽;其他生化试剂;药物多肽;药物肽;Peptide;VIP and PACAP receptor;库存;试剂盒-Elisa试剂盒;美容多肽
Mol文件	40077-57-4.mol
结构式

醋酸阿肽地尔 性质

醋酸阿肽地尔 用途与合成方法

概述

醋酸阿肽地尔是一种活性多肽为从小肠粘膜提取的一种直链肽。由28个氨基酸残基组成，其排列为一部分胰高血糖素（glucagon）和催胰液素（secretin），具有可使血管舒张降低血压的作用。从肝动脉开始，对内脏血管具有较强的作用能力，但对股动脉则全无作用。对肠液的分泌具有很强的促进作用，但对胰腺的分泌其促进作用很弱，对胃液的分泌可起抑制作用，对消化道平滑肌的收缩产生抑制作用。

应用

醋酸阿肽地尔为Mondobiotech AG和Biogen Idec公司开发出来，是由28个氨基酸组成的线性肽，主要用于急性呼吸窘迫综合症和特发性肺纤维化治疗，其效果较好且副作用小，是一种很有市场前景的多肽药物。

生物活性

Aviptadil 是一种血管活性肠多肽 (VIP) 类似物，具有强的血管舒张 (vasodilatory) 作用。Aviptadil 诱导肺血管扩张，抑制血管 SMCs 增殖、血小板聚集。Aviptadil 可用于肺纤维化、肺动脉高压 (PAH)、SARS-CoV-2 引起呼吸衰竭等的研究。

靶点

GPR14

体外研究

Aviptadil inhibits the basal proliferation of pulmonary arterial smooth muscle cells (PASMC) and the mobilization of intracellular free calcium concentration in these cells in a dose-dependent manner.Aviptadil (1 nM-10 μM) produces a concentration-dependent inhibition of CSE-induced cell death in L2 cells. At 10 μM, Aviptadil reduces CSE-stimulated MMP activity and caspase-3 activation in L2 cells.Aviptadil (10 nM-100 μM) attenuates lipopolisaccharide (LPS)-induced MMP-9 activity and its expression by alveolar macrophages (AM) in rats.

体内研究

Aviptadil (1, 3 and 10 mg/kg; intravenous bolus injection) is injected into a tail vein. No-effect dose level is 1 mg/kg. Dose level with first intolerance reactions 3 mg/kg, Lowest lethal dose level is >10 mg/kg. i.v. LD     ₅₀    of Aviptadil is >10 mg/kg in males, females and male and female combined after 24 hours and 14 days.Aviptadil (intravenous bolus injection) at 3 mg causes slightly reduced motility, slight ataxia and slight dyspnoea in all 5 male and 5 female animals 15 to 30 minutes after administration. At 10 mg, Aviptadil reveals slightly reduced motility, slight ataxia, and slight dyspnoea 15 to 60 minutes and slightly reduces muscle tone 15 to 30 minutes after administration, respectively, in all male and female animals.Nose-only inhalation exposure of CD1 mice to aerosolized.Aviptadil at a dose of 1546 µg/kg/day is well tolerated and produces no apparent changes in any of the parameters evaluated. No changes are observed after a single dose administration as high as 3920 µg/kg/day. The no-observable-adverse-effect level (NOAEL) is considered to be at least 3920 µg/kg/day fore an acute exposure and 1546 µg/kg/day for a 10 day repeated exposure.

参考质量标准

外观?白色粉末纯度(HPLC) ≥98.0%
单杂≤1.0%
醋酸根含量5.0%～12.0%
水分含量≤10.0%
肽含量≥80.0%

安全信息

MSDS信息

醋酸阿肽地尔 价格(试剂级)

醋酸阿肽地尔 上下游产品信息