(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE CAS#: 150145-89-4

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(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE

生物活性靶点体外研究体内研究 用途与合成方法 MSDS (S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE价格(试剂级) 上下游产品信息

中文名称	(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
中文同义词	(ALPHAS)-ALPHA-氨基-4-羧基-ALPHA-甲基-苯乙酸;(+)-MCPG, 99.0+ % (HPLC);(+)-Α-METHYL-4-CARBOXYPHENYLGLYCINE;(+)-Α-甲基-4-羧基苯基甘氨酸;(S)-ALPHA-甲基-4-羧基苯甘氨酸;化合物 T13452;化合物 (S)-MCPG
英文名称	(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE
英文同义词	(S)-MCPG;S(+)-ALPHA-AMINO-4-CARBOXY-ALPHA-METHYL-BENZENEACETIC ACID;(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE;4-((1S)-1-AMINO-1-CARBOXYETHYL)BENZOIC ACID;(+)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE;(S)-ALFA-METHYL-4-CARBOXYPHENYLGLYCINE;(S)-alpha-Methyl-4-carboxyphenylglycine(S)-MCPG;(+)-MCPG
CAS号	150145-89-4
分子式	C10H11NO4
分子量	209.2
EINECS号
相关类别	Glutamate receptor;Glutamate
Mol文件	150145-89-4.mol
结构式

(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE 性质

(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE 用途与合成方法

生物活性

(S)-MCPG ((+)-MCPG) 是一种有效的 I/II 类代谢型谷氨酸受体 (mGluRs) 拮抗剂，是 (RS)-MCPG (HY-100371) 的活性异构体。(S)-MCPG 可用于 mGluRs 在空间学习中的作用研究。

靶点

体外研究

(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures.

体内研究

MCPG (intraventricular injection; 20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals. On days 2 and 3, MCPG rats has a significant longer escape latency and the measure of search error is significantly longer on each of the first 3 days. On day 4, MCPG-treated animals reaches the same level of performance as control animals in Morris water maze.

安全信息

MSDS信息

(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE 价格(试剂级)

(S)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE 上下游产品信息