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L-硒代蛋氨酸
生物活性靶点体外研究体内研究 用途与合成方法 MSDS L-硒代蛋氨酸价格(试剂级) 上下游产品信息 专题
| 中文名称 | L-硒代蛋氨酸 |
|---|---|
| 中文同义词 | L(+)硒代蛋氨酸;L-硒代蛋氨;硒代蛋氨酸;L-(+)-硒代蛋氨酸;硒基-L-甲硫氨酸;(S)-(+)-2-氨基-4-(甲基硒)丁酸;-硒代蛋氨酸;L-SELENOMETHIONINE L-硒代蛋氨酸 |
| 英文名称 | L-Selenomethionine |
| 英文同义词 | (S)-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID;(S)-2-AMINO-4-(METHYLSELENO)BUTYRIC ACID;SEMET;SELENOMETHIONINE, L-(+)-;SELENO-L-METHIONINE;L-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID;L-(+)-SELENOMETHIONINE;L-SELENOMETHIONINE |
| CAS号 | 3211-76-5 |
| 分子式 | C5H11NO2Se |
| 分子量 | 196.11 |
| EINECS号 | 608-705-0 |
| 相关类别 | 医药原料药;化学试剂;氨基酸类;细胞信号和神经生物学;食品添加剂;氨基酸;功能性物质-硒代蛋氨酸;对照品;生化试剂-氨基酸类;新材料;化工原料;化工;Amino Acid Derivatives;Methionine [Met, M];Amino Acids;Antioxidant;Biochemistry;Biological-modified Amino Acids;Classes of Metal Compounds;Se (Selenium) Compounds;Semimetal Compounds;Seleno Amino Acid;amino acid;L-硒代蛋氨酸;原料;医药原料;医用原料;食品添加;优势产品;饲料添加剂;其他;高纯试剂;非天然氨基酸;化学产品;合成材料中间体 |
| Mol文件 | 3211-76-5.mol |
| 结构式 |  |
L-硒代蛋氨酸 性质
| 熔点 | 265 °C |
|---|---|
| 比旋光度 | 18 º (c=1, 1N HCl) |
| 沸点 | 320.8±37.0 °C(Predicted) |
| 折射率 | 18 ° (C=0.5, 2mol/L HCl) |
| 储存条件 | -20°C |
| 溶解度 | H2O:50 mg/mL |
| 酸度系数(pKa) | 2.26±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| 水溶解性 | soluble |
| Merck | 14,8441 |
| InChI | InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 |
| InChIKey | RJFAYQIBOAGBLC-BYPYZUCNSA-N |
| SMILES | C(O)(=O)[C@@H](N)CC[Se]C |
| LogP | 0.152 (est) |
| CAS 数据库 | 3211-76-5(CAS DataBase Reference) |
L-硒代蛋氨酸 用途与合成方法
生物活性
L-SelenoMethionine 是 Selenomethionine 的 L-异构体，是硒的主要天然食物形式。L-SelenoMethionine 是一种癌症化学预防剂，可以通过饮食补充降低癌症的发生率并诱导癌细胞凋亡。L-SelenoMethionine 还可以增加谷胱甘肽过氧化物酶的表达。
靶点
Human Endogenous Metabolite
|
体外研究
L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells.
L-SelenoMethionine (500 μM; 48 h) induce apoptosis in prostate cancer cells.
L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells.
L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation.
Cell Viability Assay
| Cell Line: | Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) |
| Concentration: | 1, 5, 10, 50, 100, 500 μM |
| Incubation Time: | 24, 48, 72 hours |
| Result: | Inhibited the growth of prostate cancer cells, with a lower IC 50 (1-90 μM) at 72 h than normal prostate cells (>500 μM). |
Apoptosis Analysis
| Cell Line: | Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) |
| Concentration: | 500 μM |
| Incubation Time: | 48 hours |
| Result: | Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells. Exhibited the nicked-end DNA labeling in prostate cancer cells. Promoted the PARP cleavage in prostate cancer cells. |
Cell Cycle Analysis
| Cell Line: | Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) |
| Concentration: | 500 μM |
| Incubation Time: | 48 hours |
| Result: | Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%). Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells. |
RT-PCR
| Cell Line: | Human thyroid epithelial cells (HTori-3) |
| Concentration: | 5 μM |
| Incubation Time: | 24 hours |
| Result: | Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells. |
体内研究
L-SelenoMethionine (0.06-12 μg/g diet; p.o. for 3 d) partially or completely prevent the decrease in the serum or plasma levels of total antioxidants in rats exposed to gamma rays, protons or HZE particles.
用途
可以用于蛋白质的结构分析。拿此产品来饲养细菌，这样最终形成的蛋白质里的特定位置就会被硒所取代，便于结构测定
安全信息
| 危险品标志 | T,N |
|---|---|
| 危险类别码 | 23/25-33-50/53 |
| 安全说明 | 20/21-28-45-60-61-28A |
| 危险品运输编号 | UN 3283 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS号 | EK7713840 |
| F | 10 |
| 危险等级 | 6.1 |
| 包装类别 | III |
| 海关编码 | 29309090 |
MSDS信息
| 提供商 | 语言 |
|---|---|
L-(+)-Selenomethionine | 英文 |
ACROS | 英文 |
SigmaAldrich | 英文 |
L-硒代蛋氨酸 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | 25996 | L(+)硒代蛋氨酸 L(+)-Selenomethionine, 99+%, ee 99+% | 3211-76-5 | 250mg | 3906元 |
| 2024/08/19 | 25996 | L(+)硒代蛋氨酸 L(+)-Selenomethionine, 99+%, ee 99+% | 3211-76-5 | 1g | 10503元 |
L-硒代蛋氨酸 上下游产品信息
上游原料
乙醇氢氧化钠盐酸甲醇乙醚硫酸四氢呋喃钠N,N-二甲基甲酰胺氯化钠丙酮氨碳酸氢钠苯过氧化氢碘甲烷氢溴酸镁氯化苄五氧化二磷硒硼酸三丁酯L-蛋氨酸甲基锂
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