4,6-亚乙基-alpha-D-葡萄糖 CAS#: 13224-99-2

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4,6-亚乙基-alpha-D-葡萄糖

生物活性靶点体外研究 用途与合成方法 MSDS 4,6-亚乙基-alpha-D-葡萄糖价格(试剂级) 上下游产品信息

中文名称	4,6-亚乙基-alpha-D-葡萄糖
中文同义词	4,6-亚乙基-Α-D-葡萄糖;4,6-O-亚乙基-Α-D-吡喃葡萄糖;4,6-O-亚乙基-Α4,6-O-亚乙基-Α-D-吡喃葡糖;4,6-O-亚乙基-Α-D-葡糖;4,6-O-亚乙基-Α-D-葡萄糖;4,6-亚乙基-alpha-D-葡萄糖;4 6 0-乙缩醛-D-葡萄糖
英文名称	4,6-O-Ethylidene-alpha-D-glucose
英文同义词	(2R,3R)-2,3-dihydroxy-3-((4R,5R)-5-hydroxy-2-methyl-1,3-dioxan-4-yl)propanal;(4aR,6S,7R,8R,8aS)-2-Methylhexahydropyrano[3,2-d][1,3]dioxine-6,7,8-triol;(4AR,7R,8R,8aS)-2-Methylhexahydropyrano-[3,2-d][1,3]dioxine-6,7,8-triol;NSC 89726;-D-glucopyranose;4,6-O-Ethylidene-α4,6-O-ETHYLIDENE-A-D-GLUCOSE;4,6-O-ETHYLIDENE-ALPHA-D-GLUCOPYRANOSE
CAS号	13224-99-2
分子式	C8H14O6
分子量	206.19
EINECS号	236-198-2
相关类别	单糖;Carbohydrate  Synthesis;Specialty  Synthesis;Monosaccharides;Sugars;Sugars, Carbohydrates & Glucosides;Biochemistry;Glucose;O-Substituted Sugars
Mol文件	13224-99-2.mol
结构式

4,6-亚乙基-alpha-D-葡萄糖 性质

4,6-亚乙基-alpha-D-葡萄糖 用途与合成方法

生物活性

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物，是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂，对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。

靶点

体外研究

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) shows poor affinity for malarial hexose transporter (PfHT1; K     _i    >50 mM). 4,6-O-ethylidene-α-D-glucose inhibits wild-type transport with a K     _i    of approximately 12 mM, but this is increased to greater than 120 mM in the Gln282-Leu mutant.  
 4,6-O-ethylidene-α-D-glucose inhibits glucose exit competitively but its penetration into human red cells is unaffected by glucose in the medium. The potentiation of the development of FDNB inhibition by sugars in the incubating medium is absent when 4,6-O-ethylidene-α-D-glucose is used and there is a slight protective action. 4,6-O-ethylidene-α-D-glucose penetrates human red cells by simple diffusion supported by its penetration of guinea-pig red cells at similar rates, by the occurrence of osmotic haemolysis in isosmotic solutions which is unaffected by copper ions and by the relatively high ether/water partition of the compound.  

安全信息

MSDS信息

4,6-亚乙基-alpha-D-葡萄糖 价格(试剂级)

4,6-亚乙基-alpha-D-葡萄糖 上下游产品信息

上游原料

乙醚硫酸氢氧化铵丙酮三聚乙醛a-无水葡萄糖酯