L-抗坏血酸-2-单磷酸酯三环己铵盐 CAS#: 23313-12-4

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L-抗坏血酸-2-单磷酸酯三环己铵盐

生物活性靶点体外研究

中文名称	L-抗坏血酸-2-单磷酸酯三环己铵盐
中文同义词	维生素C磷酸酯(L-抗坏血酸-2-磷酸酯);L-抗坏血酸-2-单磷酸酯三环己铵盐;化合物 T19390;2-磷酸抗坏血酸;维生素C磷酸酯35%;抗坏血酸2-磷酸盐
英文名称	L-ASCORBIC ACID 2-MONOPHOSPHATE TRI-CYCLOHEXYLAMMONIUM SALT
英文同义词	Vitamin C phosphate;l-ascorbic acid 2-monophosphate tris-cyclohexylammonium salt;[2-(1,2-dihydroxyethyl)-3-hydroxy-5-oxo-2H-furan-4-yl] dihydrogen phosphate;Ascorbic Acid Impurity 6;ascorbate-2-phosphate;Ascorbyl monophosphate;Ascorbyl-2-monophosphate;Ascorbyl-2-phosphate
CAS号	23313-12-4
分子式	C6H9O9P
分子量	256.1
EINECS号	601-297-5
相关类别	中间体;有机化工原料;食品添加剂;维生素C 系列
Mol文件	23313-12-4.mol
结构式

L-抗坏血酸-2-单磷酸酯三环己铵盐 性质

L-抗坏血酸-2-单磷酸酯三环己铵盐 用途与合成方法

生物活性

L-ascorbic acid 2-phosphate 是一种长效的维生素 C 衍生物 (vitamin C derivative)，可以刺激胶原蛋白的表达和形成。L-ascorbic acid 2-phosphate 可以作为培养基补充人脂肪干细胞 (hASCs) 的成骨分化。L-ascorbic acid 2-phosphate 增加成骨细胞分化过程中 hASC 中的碱性磷酸酶 (ALP) 活性和 runx2A 的表达。

靶点

IC50: alkaline phosphatase (ALP); collagen formation; runx2A

体外研究

L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc)  achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect .L-Ascorbic acid 2-phosphate (50 µM-250 µM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 µM AsA2-P and 10 nM dexamethasone (Dex), and 250 µM AsA2-P and 5 nM Dex.

Cell Proliferation Assay

安全信息

MSDS信息

L-抗坏血酸-2-单磷酸酯三环己铵盐 上下游产品信息