4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑 CAS#: 303727-31-3

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4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑

生物活性靶点体外研究 用途与合成方法 MSDS 4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑价格(试剂级) 上下游产品信息

中文名称	4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑
中文同义词	4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑;RAF激酶抑制剂(L-779450);2-氯-5-(2-苯基-5-(吡啶-4-基)-1H-咪唑-4-基)苯酚;2-氯-5-(2-苯基-5-(吡啶-4-基)-1H-咪唑-5-基)苯酚;L-779450,RAF激酶抑制剂
英文名称	2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole
英文同义词	2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole;L-779450;2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol;4-(4-Chloro-3-hydroxyphenyl)-2-phenyl-5-(4-pyridyl)-1H-iMidazole;Phenol, 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-iMidazol-5-yl]-;2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-iMidazol-4-yl)phenol;2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]phenol;4-(4-Chloro-3-hydroxyphenyl)-2-phenyl-5-(pyridin-4-yl)-1H-iMidazole
CAS号	303727-31-3
分子式	C20H14ClN3O
分子量	347.8
EINECS号
相关类别	细胞生物学试剂;小分子抑制剂;小分子抑制剂，天然产物;抑制剂;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件	303727-31-3.mol
结构式

4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑 性质

4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑 用途与合成方法

生物活性

L-779450是一种高效、低纳摩尔的B-raf抑制剂，IC50为10 nM，Kd为2.4 nM。

靶点

体外研究

L-779450 (L-779,450) shows a high degree of specificity towards Raf. The only other tested kinase inhibited is p38MAPK, which has a kinase domain structurally related to Raf. L-779450 inhibits anchorage-independent growth of human tumor lines at doses ranging from 0.3 to 2 μM. The effects of L-779450 (L-779,450) on TRAIL sensitivity are investigated here in melanoma cell lines with high TRAIL sensitivity (A-375 and SK-Mel-147), moderate sensitivity (Mel-HO, SK-Mel-13, and SK-Mel-28), and permanent resistance (MeWo, Mel-2a, and SK-Mel-103), as well as in TRAIL-selected cell lines with acquired resistance (A-375-TS and Mel-HO-TS). Despite only moderate direct effects of L-779450 on apoptosis, it strongly enhances TRAIL-induced apoptosis in sensitive melanoma cells and overrules TRAIL resistance in Mel-2a, SK-Mel-103, A-375-TS, and Mel-HO-TS. At 24 hours, 16-35% apoptosis induction is obtained.

安全信息

MSDS信息

4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑 价格(试剂级)

4-(4-氯-3-羟基苯基)-2-苯基-5-(吡啶-4-基)-1H-咪唑 上下游产品信息