喷他脒 CAS#: 100-33-4

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喷他脒

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 喷他脒价格(试剂级) 上下游产品信息

中文名称	喷他脒
中文同义词	4,4'-(戊烷-1,5-二基双(氧基))二苯脒;喷他脒;4,4'-二脒基二苯氧基戊烷;喷他脒碱;羟乙磺胺戊烷脒;4,4'-(戊烷-1,5-二基双(氧基))二苯甲脒;4,4'-(戊烷-1,5-二基双(氧基))二苯甲脒
英文名称	Pentamidine
英文同义词	4,4’-(pentamethylenedioxy)dibenzamidine;4,4’-diamidino-alpha,omega-diphenoxypentane;4,4’-diamidinodiphenoxypentane;p,p’-(pentamethylene-dioxy)bis-benzamidine;p,p’-(pentamethylenedioxy)dibenzamidine;4,4'-[1,5-PENTANEDIYLBIS(OXY)]BIS-BENZENECARBOXIMIDAMIDE;PENTAMIDINE;4,4’-(1,5-pentanediylbis(oxy))bis-benzenecarboximidamid
CAS号	100-33-4
分子式	C19H24N4O2
分子量	340.42
EINECS号	202-841-0
相关类别	黑热病药;化合物;原料药;抑制剂;医药原料药;其他原料;抗寄生虫;NEBUPENT;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics
Mol文件	100-33-4.mol
结构式

喷他脒 性质

喷他脒 用途与合成方法

生物活性

Pentamidine (MP-601205) 是一种抗微生物剂，会干扰 DNA 的生物合成。Pentamidine 抑制寄生虫 Leishmania infantum，IC50 为 2.5 μM。Pentamidine 是一种有效的选择性蛋白酪氨酸磷酸酶 (PTPases) 和再生肝磷酸酶 (PRL) 抑制剂。Pentamidine 可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究。抗肿瘤活性，抗菌活性。

靶点

IC50: 2.5 μM (     Leishmania infantum    )  
 Protein tyrosine phosphatases (PTPases)  
 Phosphatase of regenerating liver (PRL)

体外研究

Pentamidine (0-10 µg/mL; 6 days; WM9, DU145, C4-2, Hey, WM480, and A549 cells) treatment inhibits the growth of cancer cells in a concentration-dependent manner.  
 The cytotoxic properties of Pentamidine isethionate towards the promastigotes of the protozoan parasite     Leishmania infantum    is determined. The leishmanicidal activity of Pentamidine isethionate is 60 times higher after 72 h of incubation than that of Cisplatin. Pentamidine isethionate induces a higher amount of programmed cell death (PCD) than Cisplatin, which is associated with inhibition of DNA synthesis and cell-cycle arrest in the G2/M phase. Binding of Pentamidine isethionate to calf-thymus DNA (CT-DNA) induces conformational changes in the DNA double helix, consistent with a B-->A transition. The interaction of Pentamidine isethionate with ubiquitin leads to a 6% increase in the beta-sheet content of the protein.

Cell Viability Assay

体内研究

Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice.

安全信息

MSDS信息

喷他脒 价格(试剂级)

喷他脒 上下游产品信息