盐霉素钠 CAS#: 55721-31-8

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盐霉素钠

生物活性靶点体外研究体内研究 专题

中文名称	盐霉素钠
中文同义词	盐霉素钠盐;盐霉素预混;盐霉素SV钠盐的五个半水合物;盐霉素 单钠盐 水合物;盐霉素溶液, 100PPM;沙利霉素钠;沙利诺马辛;盐霉素钠盐 标准品
英文名称	Salinomycin
英文同义词	SALINOMYCIN SODIUM SALT 2.5-HYDRATE;SALINOMYCIN SV SODIUM SALT 2,5-HYDRATE;Salinomycin  hydrate  monosodium  salt;Salinomycin sodium premix;Salinomycin, monosodium salt;salinomycin monosodium salt hydrate;Salinomycin-Natrium;(2R)-2-[(5S,6R)-6-[(2S,3S,4S,6R)-6-[(2S,5R,7S,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid
CAS号	55721-31-8
分子式	C42H71NaO12
分子量	791
EINECS号	611-309-0
相关类别	驱虫保健剂;饲料添加剂;生长促进剂;促生长;预防和治疗鸡的球虫病;抗球虫促长剂;畜禽促长剂;微生物代谢物;聚醚类抗生素;化工原料;试剂盒-细胞分析试剂盒;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Organics;Antibiotics;BactericidalAntibiotics;Chemical  Structure;OthersAlphabetic;Principle;S;SA  -  SM;Pharmaceuticals
Mol文件	55721-31-8.mol
结构式

盐霉素钠 性质

盐霉素钠 用途与合成方法

生物活性

Salinomycin sodium salt (Salinomycin sodium)，一种钾离子载体抗生素，是 Wnt/β-catenin 信号传导的有效抑制剂。Salinomycin sodium salt (Salinomycin sodium) 作用于 Wnt/Fzd/LRP 复合物，阻断 Wnt 诱导的 LRP6 磷酸化，导致 LRP6 蛋白降解。Salinomycin sodium salt (Salinomycin sodium) 选择性抑制人肿瘤干细胞。

靶点

Wnt/β-catenin

体外研究

Salinomycin (0.1-8 µM) inhibits the growth of HUVECs in a dose-dependent manner, accounting for 32.1 and 59.2% inhibition at 4 and 8 µM, respectively. HUVECs exposed to 2, 4 and 8 µM of Salinomycin for 48 h show a dose-dependent reduction in cell number and a change in cell morphology. Salinomycin (4 µM) treatment effectively inhibits HUVEC migration and invasion, and significantly disrupt the capillary-like tube formation of HUVECs. Salinomycin significantly suppresses the expression levels of phosphorylated (p)-FAK in a time- and dose-dependent manner in HUVECs. Salinomycin inhibits HUVEC angiogenesis by disturbing the VEGF-VEGFR2-AKT signaling axis. Combination of RSVL and Salinomycin synergistically inhibits the proliferation of TNBC (MDA-MB-231) cells. RSVL and Salinomycin effectively reduce wound healing, colony and tumorosphere forming capability in TNBC cells. Synergistic combination of RSVL and Salinomycin induces apoptosis in both culture conditions by significant upregulation of Bax with decreased Bcl-2 expression as comparison to untreated and alone drug treatments. Salinomycin (0, 2, 4, 8 and 16 μM) significantly inhibits the proliferation of A2780 and SK-OV-3 cell lines in a dose- and time-dependent manner, (IC     _{50 24h}    : 13.8 μM, IC     _{50 48h}    : 6.888 μM and IC     _{50 72h}    : 4.382 μM for A2780 cell lines), (IC     _{50 24h}    : 12.7 μM, IC     _{50 48h}    : 9.869 μM and IC     _{50 72h}    : 5.022 μM for SK-OV-3 cell lines). Salinomycin blocks the Wnt/β-catenin pathway in EOC cells. Salinomycin (2 μM) reduces cancer cell proliferation, inhibits STAT3 phosphorylation and P38 and β-catenin expressions, and suppresses epithelial-mesenchymal transition in colorectal cancer cells. Salinomycin (1-5 μM) inhibits cancer cell proliferation and STAT3 signaling in colorectal cancer cells. Furthermore, Salinomycin activates Akt (Ser 473) and down-regulates Hsp27 (Ser 82) phosphorylation in HT-29 and SW480. Salinomycin down-regulates hTERT and reduces telomerase activity when combined with telomerase inhibitor.

体内研究

Salinomycin (5 and 10 mg/kg) significantly supresses the average tumor volume and tumor weight. Salinomycin hinders the U251 human glioma cell growth in vivo via inhibition of angiogenesis with involvement of AKT and FAK dephosphorylation. Salinomycin (0.5 mg/kg b.wt.) enhances the mean survival time of the tumor bearing Swiss albino mice.

化学性质 

白色或淡黄色结晶性粉末，微有特异臭，熔点140-142℃。易溶于丙酮、三氯甲烷、苯、乙酸乙酯、乙醚和甲醇，几乎不溶于水。大白鼠经口LD₅₀70-100mg/kg，小白鼠经口LD₅₀50mg/kg，鸡LD₅₀150mg/kg。

用途 

盐霉素钠是安全有效的抗球虫药，对大多数革兰阳性菌也有抑制作用，对鸡的球虫、柔嫩艾氏、毒害艾氏、巨型艾氏、堆形艾氏和哈氏球虫均有效。可用于鸡饲料，用量为50-60g/t，产蛋期禁用，停药期5天。马属动物忌用，用后会致死；禁止与泰妙菌素、竹桃霉素同时使用。

生产方法 

由白色链霉菌（Streptomyces albus）发酵生产。

安全信息

MSDS信息

盐霉素钠 上下游产品信息

上游原料

酒石酸铵