雌莫司汀磷酸钠 CAS#: 52205-73-9

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雌莫司汀磷酸钠

生物活性体外研究体内研究 用途与合成方法 MSDS 雌莫司汀磷酸钠价格(试剂级) 上下游产品信息

中文名称	雌莫司汀磷酸钠
中文同义词	雌莫司汀磷酸钠;雌莫司汀磷酸钠, 抗微管蛋白化疗试剂;雌莫司丁磷酸钠;(8R,9S,13S,14S,17S)-3-((双(2-氯乙基)氨基甲酰基)氧基)-13-甲基-7,8,9,11,12,13,14,15,16,17-十氢-6H-环戊二烯[A]菲-17-基磷酸二钠
英文名称	Estramustine sodium phosphate
英文同义词	ESTRAMUSTINE PHOSPHATE SODIUM;-(dihydrogenphosphate),disodiumsalt;iumphosphate;Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt;Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt;Estracyt;Estramustine phosphate disodium salt;NSC 89199
CAS号	52205-73-9
分子式	C23H33Cl2NNaO6P
分子量	544.38
EINECS号	257-735-7
相关类别	医药原料药;医药、农药及染料中间体;化学试剂;Active Pharmaceutical Ingredients;Intermediates;Other APIs
Mol文件	52205-73-9.mol
结构式

雌莫司汀磷酸钠 性质

雌莫司汀磷酸钠 用途与合成方法

生物活性

Estramustine phosphate sodium (EMP, Emcyt, Estracyt)是一种具有独特双重作用模式的抗肿瘤药。Estramustine phosphate sodium的代谢产物estrone和estradiol具有抗促性腺激素的活性，导致睾丸激素水平降低。Estramustine(estramustine phosphate sodium去磷酸化作用产生的细胞毒性代谢产物)是一种具有抗微管作用的抗前列腺肿瘤药物。

体外研究

Estramustine phosphate sodium (1 µg/mL) treatment suppressed PC3 cell growth.  
 Estramustine phosphate sodium (2 µg/mL) treatment significantly elevates phosphatidylserine eversion amount on PC3 cells. Estramustine phosphate sodium induces PC3 cell apoptosis.  
 Estramustine phosphate sodium (2 µg/mL) treatment decreases MiR-31 level. Estramustine phosphate odium induces s prostate cancer cell line PC3 apoptosis through reducing miR-31.  
 Estramustine phosphate sodium, a unique antitumour agent, is selectively taken up by prostate cells and exerts antineoplastic effects by interfering with microtubule of dynamics and by reducing plasma levels of testosterone.  
 Estrone and estradiol, products of the metabolism of Estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels similar to those achieved after surgical castration.

体内研究

Estramustine phosphate sodium (4-12 mg/kg; intraperitoneal injection; daily; for 2 weeks) inhibits PAC120 tumor growth 53% by day 35.

安全信息

MSDS信息

雌莫司汀磷酸钠 价格(试剂级)

雌莫司汀磷酸钠 上下游产品信息