2,3',4,5'-四甲氧基二苯乙烯 CAS#: 24144-92-1

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2,3',4,5'-四甲氧基二苯乙烯

生物活性靶点体外研究体内研究

中文名称	2,3',4,5'-四甲氧基二苯乙烯
中文同义词	2,3',4,5'-四甲氧基二苯乙烯;5'-四甲氧基二苯乙烯;化合物TMS;2,3',4,5'-四甲氧基二苯乙烯
英文名称	TMS
英文同义词	(E)-2,3',4,5'-TETRAMETHOXYSTILBENE;2,3',4,5'-TETRAMETHOXYSTILBENE;1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE;1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE;3,5,2’,4’-Tetramethoxystilbene;TMS - Trans-2,3',4,5'-tetramethoxystilbene;CS-961;Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy-
CAS号	24144-92-1
分子式	C18H20O4
分子量	300.35
EINECS号
相关类别	抑制剂;Antitumour
Mol文件	24144-92-1.mol
结构式

2,3',4,5'-四甲氧基二苯乙烯 性质

2,3',4,5'-四甲氧基二苯乙烯 用途与合成方法

生物活性

TMS ((E)-2,3',4,5'-tetramethoxystilbene) 是一种选择性和竞争性 CYP1B1 抑制剂，IC50 为 6 nM，Ki 值为 3 nM。TMS 对 CYP1A1 (IC50=300 nM) 和 CYP1A2 (IC50=3.1 μM) 的抑制作用较小。TMS 是白藜芦醇的甲基化衍生物，具有抗癌活性。

靶点

体外研究

TMS, an analogue of resveratrol, is considered to be a potential cancer preventive agent since it is a potent inhibitor of CYP1B1. To assess survival of MCF-7 cells exposed to 1 μM benzo[a]pyrene (BP), 1 μM BP+1 μM TMS and 1 μM BP+4 μM TMS, cells ae incubated for up to 72 h without a media change. Luminescence units from exposed cells, expressed as a percentage of luminescence units from solvent (DMSO)-treated cells at the same time intervals. In all exposure groups, cell viability remains >90% for the first 24 h, but by 72 h, cell survival drops to 60-70%.

体内研究

To determine the contribution of CYP1B1 in development of hypertension in spontaneously hypertensive rats (SHR), the effect of TMS is examined on in SHR and WKY rats. Systolic BP steadily increases in SHR from 4 weeks of age. Starting from 8 weeks of age, daily injections of TMS reduce systolic BP in SHR to levels observed at the beginning of the experiment (207±7 vs. 129±2 mmHg). Systolic BP is not altered in WKY injected with TMS or its vehicle (129±7 vs. 127±4 mmHg) .

安全信息

MSDS信息

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