1-苯基双胍 CAS#: 102-02-3

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1-苯基双胍

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 1-苯基双胍价格(试剂级) 上下游产品信息

中文名称	1-苯基双胍
中文同义词	苯基双胍;1-苯基双胍
英文名称	PHENYLBIGUANIDE
英文同义词	phenyldiguanide;1-PHENYLBIGUANIDE;N-PHENYLIMINODICARBONIMIDIC-DIAMIDE;PHENYLBIGUANIDE;2-(N2-Phenylamidino)guanidine;1-phenyl-biguanid;n-phenyl-n’-guanylguanidine;p1426
CAS号	102-02-3
分子式	C8H11N5
分子量	177.21
EINECS号	202-998-5
相关类别	胍;有机化学;AgonistsOrganic  Building  Blocks;Guanidines;Neurotransmitters;Nitrogen  Compounds;Serotonergics
Mol文件	102-02-3.mol
结构式

1-苯基双胍 性质

1-苯基双胍 用途与合成方法

生物活性

1-Phenylbiguanide (Phenylbiguanide, PBG, N-Phenylbiguanide)是一种 5-hydroxytryptamine3 (5-HT3) receptor 激动剂，EC50为3.0 μM。

靶点

体外研究

Phenylbiguanide (1-Phenylbiguanide) is a 5-HT     ₃    receptor selective agonist with pEC     ₅₀    s of 5.57, 4.07, and 4.47 for r5-HT     _3A(b)    , h5-HT     _3A    , m5-HT     _3A(b)    , respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01).

体内研究

In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.

安全信息

MSDS信息

1-苯基双胍 价格(试剂级)

1-苯基双胍 上下游产品信息

下游产品