氰美马嗪 CAS#: 3546-03-0

微信扫码

氰美马嗪

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 氰美马嗪价格(试剂级) 上下游产品信息

中文名称	氰美马嗪
中文同义词	赛马咪嗪;氰美马嗪;氰美马嗪杂质;赛马咪嗪杂质;西阿米嗪;化合物 T15026;10-(3-(二甲基氨基)-2-甲基丙基)-10H-吩噻嗪-2-甲腈
英文名称	cyamemazine
英文同义词	Cianatil;Kyamepromazine;RP-7204;TH-2602;10-[3-(dimethylamino)-2-methyl-propyl]phenothiazine-2-carbonitrile;10-[3-(dimethylamino)-2-methylpropyl]phenothiazine-2-carbonitrile;10-[3-(DiMethylaMino)-2-Methylpropyl]-10H-phenothiazine-2-carbonitrile;2-Cyano-10-(3-diMethylaMino-2-Methylpropyl)phenothiazine
CAS号	3546-03-0
分子式	C19H21N3S
分子量	323.46
EINECS号	222-594-2
相关类别	化工原料;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol文件	3546-03-0.mol
结构式

氰美马嗪 性质

氰美马嗪 用途与合成方法

生物活性

Cyamemazine 是一种抗精神病药，其中含有吩噻嗪发色团，通常被用作抗焦虑药。Cyamemazine 是具有抗精神病活性的有效的 5-HT3 (Ki 为 12 nM), 5-HT2A (Ki 为 1.5 nM) 和 5-HT2C (Ki 为 75 nM) 受体拮抗剂。

靶点

体外研究

Cyamemazine exhibits a high affinity for dopamine receptors, which is consistent with its antipsychotic activity. The antagonist activity of Cyamemazine at muscarinic receptors is consistent with its affinity for M     ₁    (     K   _i      = 13 nM), M     ₂    (     K   _i      = 42 nM), M     ₃    (     K   _i      = 321 nM), M     ₄    (     K   _i      = 12 nM), and M     ₅    (     K   _i      = 35 nM) receptors.

体内研究

Cyamemazine behaves as an antagonist at the 5-HT     ₃    , 5-HT     _2C    , and 5-HT     _2A    receptors in 5-HT     ₃    -dependent contraction of isolated guinea pig ileum and bradycardic responses in rats, in 5-HT     _2C    -dependent phospholipase C stimulation in the rat brain membrane, and in 5-HT     _2A    -dependent contraction of isolated rat aorta rings and isolated guinea pig trachea. Cyamemazine antagonizes 5-HT     ₃    and 5-HT     _2C    receptors and that this effect is partially involved in its therapeutic activity in anxiety disorders. Acute administration of low doses of Cyamemazine can reduces extracellular dopamine and metabolite concentrations in rat striatum.

安全信息

MSDS信息

氰美马嗪 价格(试剂级)

氰美马嗪 上下游产品信息

上游原料

氨基钠氰化亚铜