光克洛 CAS#: 149402-51-7

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光克洛

生物活性体外研究体内研究

中文名称	光克洛
中文同义词	光克洛;光克洛(HPPH);(3S,4S)-14-乙基-9-(1-(己基氧基)乙基)-4,8,13,18-四甲基-20-氧代-3-PHORBINE丙酸
英文名称	14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid
英文同义词	Photochlor (HPPH);3-Phorbinepropanoic acid, 14-ethyl-9-[1-(hexyloxy)ethyl]-4,8,13,18 -tetramethyl-20-oxo-, (3S,4S)-;Sulcardine;14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid;2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a;(3S,4S)-14-Ethyl-9-[1-(hexyloxy)ethyl]-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid;3-Devinyl-3-(1'-hexyloxy)ethylpyropheophorbide A;Photochlor
CAS号	149402-51-7
分子式	C39H48N4O4
分子量	636.82
EINECS号
相关类别	科研原药系列;原料药【仅供科研】;合成材料中间体
Mol文件	149402-51-7.mol
结构式

光克洛 性质

光克洛 用途与合成方法

生物活性

HPPH (Photochlor) 是第二代光敏剂，用于光动力疗法 (PDT)。

体外研究

Fluorescence image of 4T1 cells incubated with 0.49 µg/mL GO-PEG, 1 μM HPPH (free HPPH) or equivalent amount of GO-PEG-HPPH (1 µM HPPH and 0.49 µg/mL GO-PEG) after 24 h. The cellular uptake of GO-PEG-HPPH and HPPH is investigated with 4T1 murine mammary cancer cells. The cells are incubated with GO-PEG-HPPH and free HPPH at equivalent HPPH concentration (1 µM) for 24 h and then observed with a confocal microscope. Cells treated with GO-PEG-HHPH shows stronger fluorescence signal than those treated with free HPPH. In fact, the fluorescence of HPPH is rather weak.

体内研究

Tumors are treated with an immune-enhancing PDT regimen followed by a tumor-controlling PDT regimen can leads to enhancement of anti-tumor immunity, while retaining effective control of primary tumor growth. To test this hypothesis, a combination treatment regimen is devised in which Colo26-HA tumor-bearing BALB/c mice are treated with a HPPH-PDT regimen known to lead to enhanced anti-tumor immunity (0.4 μmoles/kg HPPH followed 18 h later by illumination with 665 nm light for a total dose of 48 J/cm     ²    ). Following illumination, mice are rested for 9 days; on the ninth day, mice are injected with HPPH. On day 10 following the first treatment, tumors are treated with a tumor control treatment regimen (illumination with 665 nm light for a total dose of 132 J/cm     ²    given).

安全信息

MSDS信息

光克洛 上下游产品信息