丝拉克肽 CAS#: 12279-41-3

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丝拉克肽

理化性质贮存生物活性靶点体外研究 用途与合成方法 MSDS 丝拉克肽价格(试剂级) 上下游产品信息

中文名称	丝拉克肽
中文同义词	人ACTH (1-39)肽;丝拉克肽;六氟硅酸;丝拉克肽, ≥97% (HPLC);促肾上腺皮质激素(1-39);SERACTIDE、丝拉克肽;促肾上腺皮质激素ACTH(1-39);促肾上腺皮质激素ACTH(1-39), HUMAN丝拉克肽
英文名称	Seractide
英文同义词	CORTICOTROPIN (HUMAN);CORTICOTROPHIN;CORTICOTROPIN A;H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-GLY-ALA-GLU-ASP-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE-OH;ACTH (1-39) (huMan) Corticotropin;Adrenocorticotropic Hormone (ACTH) (1-39);Seractide acetate;Adrenocorticotropic Hormone (ACTH) (1-39), human
CAS号	12279-41-3
分子式	C207H308N56O58S1
分子量	4541.07
EINECS号	634-154-0
相关类别	原料药;多肽;多肽中间体;细胞生物学;细胞信号和神经生物学;多肽系列;生化试剂-蛋白质;药物多肽;Peptide;Melanocortin receptor
Mol文件	12279-41-3.mol
结构式

丝拉克肽 性质

丝拉克肽 用途与合成方法

理化性质

类白色粉末,有特臭。

贮存

储存温度：-20℃

生物活性

Adrenocorticotropic Hormone (ACTH) (1-39), human 是一种黑皮质素受体 (melanocortin receptor) 激动剂。

靶点

Melanocortin receptor

体外研究

Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH 1-39), a member of the melanocortin family, stimulates production of CS by the adrenals, but melanocortin receptors are also found in the central nervous system (CNS) and on immune cells. ACTH 1-39 protects neurons in vitro from several apoptotic, excitotoxic and inflammation-related insults. The conditioned medium (CM) is prepared from untreated astroglia (AS) cultures and from AS cultures treated with 200 nM ACTH 1-39 for 24 h, washed to remove ACTH 1-39, then incubated for another 24 h in DMEM. In initial experiments, no difference is found in oligodendroglia (OL) viability in the presence of OL definedmediumwith 2% newborn calf serum (NCS) or AS CM (prepared in DMEM with no serum). After 24 h, OL death under each condition varies between 1 and 4%. Similar results for OL viability are obtained with microglia (MG) CM. In subsequent experiments, controls in each experiment consist of OL in defined medium with 2% NCS.

参考质量标准

外观?白色粉末纯度(HPLC) ≥95.0%
醋酸根含量5.0%～12.0%
水分含量≤8.0%
肽含量≥80.0%

用途 

可用于生产促肾上腺皮质激素（ACTH），助应素。在兽药生产上，可用于促黄体激素和促卵泡激素的生产。

安全信息

MSDS信息

丝拉克肽 价格(试剂级)

丝拉克肽 上下游产品信息