舒缓激肽片段1-7 CAS#: 23815-87-4

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舒缓激肽片段1-7

生物活性体外研究 用途与合成方法 MSDS 舒缓激肽片段1-7价格(试剂级) 上下游产品信息

中文名称	舒缓激肽片段1-7
中文同义词	舒缓激肽片段1-7;BRADYKININ (1-7)|舒缓激肽片段1-7;1-7-血管舒缓激肽;血管舒缓激肽(BK) 片段 (1-7);缓激肽1-7;缓激肽BRADYKININ(1-7)
英文名称	H-ARG-PRO-PRO-GLY-PHE-SER-PRO-OH ACETATE SALT
英文同义词	H-ARG-PRO-PRO-GLY-PHE-SER-PRO-OH ACETATE SALT;H-ARG-PRO-PRO-GLY-PHE-SER-PRO-OH ACOH;ARG-PRO-PRO-GLY-PHE-SER-PRO;ARG-PRO-PRO-GLY-PHE-SER-PRO ACETATE;BRADYKININ FRAGMENT 1-7;BRADYKININ (1-7);BRADYKININ 1-7 ACETATE;RPPGFSP
CAS号	23815-87-4
分子式	C35H52N10O9
分子量	756.85
EINECS号
相关类别	细胞生物学;细胞信号和神经生物学;Peptide;Bradykinins;Peptides  and  Proteins;Peptides  for  Cell  Biology
Mol文件	23815-87-4.mol
结构式

舒缓激肽片段1-7 性质

舒缓激肽片段1-7 用途与合成方法

生物活性

Bradykinin (1-7) 是一种氨基截短的激肽肽。Bradykinin (1-7) 是由内肽酶切割形成的一种 Bradykinin 代谢物。

体外研究

The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8).

安全信息

MSDS信息

舒缓激肽片段1-7 价格(试剂级)

舒缓激肽片段1-7 上下游产品信息