BK CAS#: 58-82-2

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BK

生物活性靶点体外研究体内研究

中文名称	BK
中文同义词	亮氨酸脑啡肽 乙酸盐 水合物;BK 舒缓激肽;舒缓激肽;缓激肽, >98%;[DES-PRO2]-BRADYKININ; ANGIOTENSIN I CONVERTING ENZYME (ACE I) INHIBITOR;BRADYKININ游离态;舒缓激肽H-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-OH;化合物BRADYKININ
英文名称	BRADYKININ
英文同义词	RPPGFSPFR;BRADYKININ;BRADYKININ, TYROSYL;BRADYKININ, LYSYL;BRADYKININ, METHIONYL-LYSYL;BRADYKININ, HUMAN;BRADYKININ (HUMAN, BOVINE, RAT, MOUSE);ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG
CAS号	58-82-2
分子式	C50H73N15O11
分子量	1060.21
EINECS号	200-398-8
相关类别	多肽-客户肽;多肽;目录多肽;peptide;Chemical and pharmaceutical intermediates
Mol文件	58-82-2.mol
结构式

BK 性质

BK 用途与合成方法

生物活性

Bradykinin是由激肽释放酶-激肽系统产生的活性肽。 它是炎症调节因子，也被认为是几种血管和肾功能以及神经调节因子。

靶点

体外研究

Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF. Bradykinin has been reported to be involved in the progression of many types of cancer. Bradykinin treatment promotes the invasion and migration of colorectal cancer cells. Bradykinin treatment stimulates ERK1/2 activation and IL-6 production. Exogenous bradykinin markedly inhibits TF expression in mRNA and protein level induced by LPS in a dose-dependent manner. The NO synthase antagonist L-NAME and PI3K inhibitor LY294002 dramatically abolish the inhibitory effects of bradykinin on tissue factor expression.

体内研究

Application of 1 μM bradykinin to the ovary produces significant decreases in heart rate and mean arterial pressure. In vagotomized animals, application of 1 μM bradykinin to the ovary produces bradycardia and hypotension similar to the responses evoked when vagal innervation is intact. Vascular bradykinin can improve pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. The pancreatic microcirculatory blood flow volume and velocity in the vascular bradykinin treatment group increases gradually after 48 h. PI3K/Akt signaling pathway activation induced by bradykinin administration reduces the activity of GSK-3β and MAPK, and reduces NF-x03BA;B level in the nucleus, thereby inhibiting TF expression. Consistent with this, intraperitoneal injection of C57/BL6 mice with bradykinin also inhibits the thrombus formation induced by ligation of inferior vena cava.

参考质量标准

外观:白色粉末
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%

类别

有毒物品

毒性分级

剧毒

急性毒性

腹腔-大鼠 TDL0:0.00053 毫克/公斤;静脉-大鼠TDL0:0.000212毫克/公斤

可燃性危险特性

热分解排出有毒氮氧化物气体

储运特性

库房通风, 低温, 干燥, 密闭, 与食品原料分开存放

灭火剂

水,泡沫,沙土,二氧化碳,干粉

安全信息

MSDS信息

BK 上下游产品信息