异甜菊醇 CAS#: 27975-19-5

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异甜菊醇

生物活性体外研究 用途与合成方法 MSDS 异甜菊醇价格(试剂级) 上下游产品信息 专题

中文名称	异甜菊醇
中文同义词	异甜菊醇;异甜菊醇, 来源于甜叶菊;异甜菊醇标准品;ISOSTEVIOL 异甜菊醇 标准品;ISOSTEVIOL 异甜菊醇;异甜菊醇、异斯特维醇;异甜菊醇, BR;异甜菊醇对照品
英文名称	ISOSTEVIOL
英文同义词	Isosteviol (NSC 231875);(4α,8β,13β)-13--Methyl-16-oxo-17-norkauran-18-oic acid;Ccris 6121;Nsc 231875;17-NORKAURAN-18-OIC ACID, 13-METHYL-16-OXO-, (4-ALPHA,8-BETA,13-BETA)-;ISOSTEVIOL;(4-alpha,8-beta,13-beta)-13-methyl-16-oxo-17-norkauran-18-oicacid;13-beta-kauran-18-oicacid,13-methyl-16-oxo-17-nor-8-bet
CAS号	27975-19-5
分子式	C20H30O3
分子量	318.45
EINECS号
植物来源	甜叶菊
相关类别	标准品;提取物;中药对照品;植物提取物;对照品;标准品-对照品;对照品-中药对照品;标准品 -中药标准品;二萜;标准品，对照品;医药、农药及染料中间体;Chiral Reagents;Miscellaneous Natural Products;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件	27975-19-5.mol
结构式

异甜菊醇 性质

异甜菊醇 用途与合成方法

生物活性

Isosteviol ((-)-Isosteviol) 是一种甜菊糖苷衍生物，是甜菊糖苷通过酸催化水解产生的。Isosteviol 抑制 DNA 聚合酶和 DNA 拓扑异构酶，并具有抗菌，抗癌和抗结核作用。

体外研究

Isosteviol ((-)-Isosteviol) dose-dependently relaxed the vasopressin (10     ^-8    M)-induced vasoconstriction in isolated aortic rings with or without endothelium. However, in the presence of potassium chloride (3×10     ^-2    M), the vasodilator effect of isosteviol on arterial strips disappeared. Only the inhibitors specific for the ATP-sensitive potassium (KATP) channel or small conductance calcium-activated potassium (SKCa) channel inhibited the vasodilator effect of isosteviol in isolated aortic rings contracted with 10     ^-8    M vasopressin.  
 The attenuation by isosteviol of the vasopressin- and phenylephrine-induced increase in [Ca     ²⁺    ]i was inhibited by glibenclamide, apamin and 4-aminopyridine but not by charybdotoxin. Furthermore, the inhibitory action of isosteviol on [Ca     ²⁺    ]i was blocked when A7r5 cells co-treated with glibenclamide and apamin in conjunction with 4-aminopyridine were present.  
 Isosteviol (1-100 micromol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 2'7'-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive oxygen species generated by the effects of angiotensin II.  

化学性质 

白色结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于甜菊（Stevia rebaudiana Bertoni）又名甜叶菊、甜草。

用途 

异甜菊醇具有抗高血压、降低血糖、抑制癌细胞的作用。

用途 

用于含量测定/鉴定/药理实验等

安全信息

MSDS信息

异甜菊醇 价格(试剂级)

异甜菊醇 上下游产品信息