二氢丹参酮 CAS#: 20958-18-3

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二氢丹参酮

生物活性靶点体外研究 用途与合成方法 MSDS 二氢丹参酮价格(试剂级) 上下游产品信息

中文名称	二氢丹参酮
中文同义词	4,8-二甲基-8,9-二氢菲并[3,2-b]呋喃-7,11-二酮;二氢丹参酮;二氢丹参酮(标准品);去氢异丹参酮 I;二氢异丹参酮I;2-B]呋喃-7;8-二甲基-8;9-二氢菲并[3
英文名称	Dihydrotanshinone
英文同义词	Dihydroisotanshinone I;4,8-Dimethyl-8,9-dihydrophenanthro[3,2-b]furan-7,11-dione;Dihydrotanshinone;8,9-Dihydro-4,8-dimethylphenanthro[3,2-b]furan-7,11-dione;Phenanthro(3,2-B)furan-7,11-dione, 8,9-dihydro-4,8-dimethyl-;Dihydrotanshinone 4,8-Dimethyl-8,9-dihydrophenanthro[3,2-b]furan-7,11-dione;DIHYDROTANSHINON;4,8-Dimethyl-8,9-Dihydronaphtho[2,1-F][1]BenzofuraN-7,11-Dione
CAS号	20958-18-3
分子式	C18H14O3
分子量	278.3
EINECS号
植物来源	丹参
相关类别	医药原料;分析标准品;中药标准品;中药对照品;对照品-中药对照品;其它天然产物;标准品 -中药标准品;分析试剂-标准品;医药化工类;天然产物;Herb extract
Mol文件	20958-18-3.mol
结构式

二氢丹参酮 性质

二氢丹参酮 用途与合成方法

生物活性

Dihydroisotanshinone I是一种来自应用广泛的传统中药丹参的活性物质。

靶点

体外研究

Dihydroisotanshinone I can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. It inhibits the protein expression of p-STAT3 and decreases the translocation of STAT3 into nuclear chromatin. It also suppresses the expression of tumor epithelial-mesenchymal transition genes, including RhoA and SNAI1. Pretreating the cells with dihydroisotanshinone I at concentrations ranging from 2.5 μM to 20 μM for 24 hours cause dose-dependent protection against hepatotoxicity induced by menadione. Adding dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibit NADH-induced superoxide production dose-dependently.

用途 

具有抗菌，抗真菌活性，对金黄色葡萄球菌、人型结核杆菌、分支杆菌、真皮菌等都有一定的抑制作用。还有抑制血小板聚集、抗氧化剂、扩张冠状血管等活性。

安全信息

MSDS信息

二氢丹参酮 价格(试剂级)

二氢丹参酮 上下游产品信息