盐酸胡芦巴碱 CAS#: 6138-41-6

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盐酸胡芦巴碱

生物活性体外研究体内研究 用途与合成方法 MSDS 盐酸胡芦巴碱价格(试剂级) 上下游产品信息 专题

中文名称	盐酸胡芦巴碱
中文同义词	N-甲基烟酸内盐盐酸盐;盐酸葫芦巴碱;胡卢巴碱盐酸盐;盐酸葫芦巴碱\葫芦巴碱盐酸盐、N-甲基烟酸内盐盐酸盐;葫芦巴碱盐酸盐(标准品);胡芦巴碱盐酸盐;盐酸胡芦巴碱;葫芦巴碱盐酸盐
英文名称	Trigonelline hydrochloride
英文同义词	1-METHYLPYRIDINIUM-3-CARBOXYLATE HYDROCHLORIDE;N-METHYLNICOTINIC ACID BETAINE HYDROCHLORIDE;TRIGONELLIN HYDROCHLORIDE;TRIGONELLINE HYDROCHLORIDE;TRIGONELLINE HCL;TIMTEC-BB SBB000182;3-carboxy-1-methylpyridinium chloride;EINECS 228-119-5
CAS号	6138-41-6
分子式	C7H8ClNO2
分子量	173.6
EINECS号	228-119-5
植物来源	葫芦巴
相关类别	吡啶;小分子抑制剂;植物提取物;对照品;植提标准品;中药对照品;标准品;小分子抑制剂，天然产物;标准品 -中药标准品;标准品，对照品;食品原料;chemical reagent;pharmaceutical intermediate;phytochemical;Alkaloids;Biochemistry;Pyridine Alkaloids;Pyridinium Compounds;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
Mol文件	6138-41-6.mol
结构式

盐酸胡芦巴碱 性质

盐酸胡芦巴碱 用途与合成方法

生物活性

Trigonelline chloride 是一种大量存在于咖啡中并且具有潜在抗糖尿病活性的生物碱。Trigonelline chloride 具有抗 HSV-1，抗菌和抗真菌活性。

体外研究

It is found that Trigonelline chloride (TG) significantly rescues the morphology of the H9c2 cells. Treatment of cells with Trigonelline chloride attenuates H     ₂    O     ₂    induced cell deaths and improves the antioxidant activity. In addition, Trigonelline chloride regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H     ₂    O     ₂    induced oxidative stress in H9c2 cells. For evident, flow cytometer results also confirm that Trigonelline chloride significantly reduces the H     ₂    O     ₂    induced necrosis and apoptosis in H9c2 cells. However, further increment of Trigonelline chloride concentration against H     ₂    O     ₂    can induce the necrosis and apoptosis along with H     ₂    O     ₂    .

体内研究

Trigonelline chloride decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. In nicotinamide/streptozotocin-treated rats, Trigonelline chloride significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength. Trigonelline chloride differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders, intensifying the osteoporotic changes in streptozotocin-treated rats and favorably affecting bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats.

化学性质 

可溶于甲醇、乙醇、DMSO等有机溶剂，来源于葫芦巴。

用途 

盐酸葫芦巴碱具有降血糖的作用。

安全信息

MSDS信息

盐酸胡芦巴碱 价格(试剂级)

盐酸胡芦巴碱 上下游产品信息

下游产品

吡啶