木兰脂素 CAS#: 31008-18-1

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木兰脂素

生物活性靶点体外研究 用途与合成方法 MSDS 木兰脂素价格(试剂级) 上下游产品信息

中文名称	木兰脂素
中文同义词	望春花素;木兰脂素;木兰脂素, 来源于辛夷;木兰脂素(标准品);木兰脂素(分析标准品);木兰苷;木兰脂素对照品;(1S,3AR,4S,6AR)-1-(3,4-二甲氧基苯基)-4-(3,4,5-三甲氧基苯基)六氢呋喃并[3,4-C]呋喃
英文名称	magnolin
英文同义词	1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl);Medioresinol dimethyl ether;tetrahydro-4-(3,4,5-trimethoxyphenyl)-,(1S,3aR,4S,6aR)-;Magnolin;Maglin;Magnolin, 98%, from Magnolia liliflora Desr.;(1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan;1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-, (1S,3aR,4S,6aR)-
CAS号	31008-18-1
分子式	C23H28O7
分子量	416.46
EINECS号	202-110-6
相关类别	中药标准品;中药对照品;分析标准品;标准品;植物提取物;对照品;标准品-对照品;对照品-中药对照品;木脂素;分析试剂-对照品;标准品，对照品;化工原料;Miscellaneous Natural Products
Mol文件	31008-18-1.mol
结构式

木兰脂素 性质

木兰脂素 用途与合成方法

生物活性

Magnolin 是 Magnolia flos (Shin-Yi) 的主要成分，靶向作用于ERK1 和 ERK2，IC50s 分别为 87 nM 和 16.5 nM，从而抑制Ras/ERKs/RSK2信号通路。

靶点

体外研究

Magnolin is a natural compound abundantly found in     Magnolia    flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Magnolin targets the active pockets of ERK1 and ERK2, which are important signaling molecules in cancer cell metastasis. Magnolin inhibits NF-κB transactivation activity by suppressing the ERKs/RSK2 signaling pathway. Magnolin inhibits the production of tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) by inhibiting extracellular signal-regulated kinases (ERKs), which are key signaling molecules in the regulation of cell proliferation, transformation and cancer cell metastasis. JB6 Cl41 cell migration enhanced by EGF treatment is dramatically suppressed by Magnolin treatment in a dose-dependent manner. Magnolin inhibits ERK1/2/RSK2 signaling-mediated IκBα phosphorylation at Ser32, resulting in the inhibition of NF-κB activation and cell migration.

化学性质 

白色结晶粉末，溶于氯仿，来源于望春花，木兰科辛夷Magnolia denudata Desr的花蕾。

用途 

木兰脂素具有抗过敏，抗炎，降压，抑菌的作用。

用途 

用于含量测定/鉴定/药理实验等

安全信息

MSDS信息

木兰脂素 价格(试剂级)

木兰脂素 上下游产品信息