WARANGALONE CAS#: 4449-55-2

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WARANGALONE

生物活性靶点体外研究 用途与合成方法 MSDS WARANGALONE价格(试剂级) 上下游产品信息

中文名称	WARANGALONE
中文同义词	攀登鱼藤异黄酮
英文名称	warangalone
英文同义词	warangalone;5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)-6-pyrano[3,2-g][1]benzopyranone;Warangalone (Scandenolone);2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one,5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methyl-2-buten-1-yl)-;Scandenolone;5-hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-10-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one;5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-10-(3-methylbut-2-en-1-yl)pyrano[3,2-g]chromen-4(8H)-one
CAS号	4449-55-2
分子式	C25H24O5
分子量	404.46
EINECS号
相关类别	标准品;植物提取物;标准品 -对照药材;黄酮
Mol文件	4449-55-2.mol
结构式

WARANGALONE 性质

WARANGALONE 用途与合成方法

生物活性

Warangalone 是抗疟疾化合物，能够抑制 3D7 (氯喹敏感) 和 K1 (氯喹耐药) 寄生虫的生长， IC50 值分别为 4.8 μg/mL 和 3.7 μg/mL。 Warangalone 还可以抑制环 AMP 依赖性蛋白激酶催化亚基 (cAK)，其 IC50 值为 3.5 μM。

靶点

IC50: 4.8 μg/mL (3D7), 3.7 μg/mL (K1)  
 IC50: 3.5 μM (cAK)

体外研究

Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC     ₅₀    s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC     ₅₀    of 3.5 μM. When HL-60 cells are exposed to Warangalone (30 μM) for 24 h, Warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. A time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells.

安全信息

MSDS信息

WARANGALONE 价格(试剂级)

WARANGALONE 上下游产品信息