六氢姜黄素 CAS#: 36062-05-2

微信扫码

六氢姜黄素

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 六氢姜黄素价格(试剂级) 上下游产品信息

中文名称	六氢姜黄素
中文同义词	六氢姜黄素;六氢姜黄素?, BR;COX-2抑制剂(HEXAHYDROCURCUMIN);六氢姜黄素 标准品;5-羟基-1,7-双(4-羟基-3-甲氧基苯基)庚烷-3-酮
英文名称	HEXAHYDROCURCUMIN
英文同义词	HEXAHYDROCURCUMIN;5-Hydroxy-1-(4-hydroxy-3-Methoxycyclohexyl)-7-(4-hydroxy-3-Methoxyphenyl)heptan-3-one;(RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone;1,7-Bis(3-methoxy-4-hydroxyphenyl)-5-hydroxy-3-heptanone;1,7-Bis(4-hydroxy-3-methoxyphenyl)-5-hydroxyheptan-3-one;5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone;Hexahydrocurcumin, BR;3-Heptanone, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-
CAS号	36062-05-2
分子式	C21H26O6
分子量	374.43
EINECS号
相关类别	细胞生物学试剂;对照品;中药对照品;标准品;植物提取物;标准品 -对照药材;其它酚类;标准品，对照品;对照品;标准品-对照品
Mol文件	36062-05-2.mol
结构式

六氢姜黄素 性质

六氢姜黄素 用途与合成方法

生物活性

Hexahydrocurcumin 是姜黄素的主要代谢产物之一，是一种选择性的口服活性 COX-2 抑制剂，对 COX-1 无活性。Hexahydrocurcumin 具有抗氧化，抗癌和抗炎的作用。

靶点

体外研究

Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) treatment significantly decreased the viability of HT-29 colon cancer cells in a time- and concentration-dependent. The respective IC     ₅₀    values for 24 and 48 h of Hexahydrocurcumin exposureare 77.05 and 56.95, respectively.  
 Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 µM) markedly reduces the COX-2 expression. The level of COX-1 is not altered.  
 Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 µM) markedly reduces the COX-2 protein. The level of COX-1 protein is not altered.  
 Hexahydrocurcumin (7-14 μM; 24 hours) attenuates lipopolysaccharide (LPS)-elicited increase of prostaglandin E     ₂    (PGE     ₂    ) in murine macrophages (RAW 264.7) in a concentration-dependent manner.

Cell Viability Assay

RT-PCR

Western Blot Analysis

体内研究

Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci (ACF) in colon cancer rats. Hexahydrocurcumin also markedly decreases COX-2 protein expression. The levels of COX-1 protein is not different from normal rats.

安全信息

MSDS信息

六氢姜黄素 价格(试剂级)

六氢姜黄素 上下游产品信息