烟曲霉毒素c CAS#: 118974-02-0

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烟曲霉毒素c

背景生物活性体外研究

中文名称	烟曲霉毒素c
中文同义词	烟曲霉素C, 来源于烟曲霉菌;烟曲酶毒素C;烟曲霉震颤素C;烟曲霉毒素C;烟曲霉素C
英文名称	FUMITREMORGIN C
英文同义词	Fumitremorgin C, Aspergillus. fumigatus - CAS 118974-02-0 - Calbiochem;FuMitreMorgin CFuMitreMorg;(5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione;12alpha-Fumitremorgin C;5H,14H-Pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione,1,2,3,5a,6,11,12,14a-octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-,(5aS,12S,14aS)-;Fumitremorgin C, 98%, from Aspergillus fumigatus;12α-Fumitremorgin C;Fumitremorgin C, from Aspergillus fumigatus
CAS号	118974-02-0
分子式	C22H25N3O3
分子量	379.45
EINECS号
相关类别	微生物代谢物;抗生素;生化试剂;生物碱;医药原料
Mol文件	118974-02-0.mol
结构式

烟曲霉毒素c 性质

烟曲霉毒素c 用途与合成方法

背景

烟曲霉毒素是由串珠镰刀菌（Fusarium moniliforme）产生，通常在霉变的玉米中发现，真菌毒素。烟曲霉毒素发现较晚，最早于1988年报告，最常见的是烟曲霉毒素B、烟曲霉毒素C。

生物活性

Fumitremorgin C是有效，选择性的ABCG2/BRCP抑制剂。

体外研究

Multidrug resistance (MDR) is a major problem in cancer chemotherapy. Fumitremorgin C is extremely effective in reversing resistance to mitoxantrone, doxorubicin, and topotecan in multidrug-selected cell lines. In MCF-7/mtxR (a mitoxantroneselected cell line), fumitremorgin C reverses mitoxantrone resistance (114-fold) and doxorubicin resistance (3-fold). Fumitremorgin C (5/AM)significantly potentiates the toxicity of mitoxantrone (93-fold), doxorubicin (26-fold), and topotecan (24-fold) in S1M1-3.2 cells. Reversal of resistance is associated with an increase in drug accumulation. Fumitremorgin C does not reverse drug resistance in cells with elevated expression of Pgp or MRP. Fumitremorgin C almost completely reverses resistance mediated by BCRP     in vitro    and is a pharmacological probe for the expression and molecular action of this transporter. Fumitremorgin C also enhances the toxicity of mitoxantrone and topotecan in vector-transfected MCF-7 cells (2.5–5.6 fold). It reduces the IC     ₅₀    of topotecan in BCRP-overexpressing cells below that observed in the untreated vector-transfected cells. .

安全信息

MSDS信息

烟曲霉毒素c 上下游产品信息