N,N,N',N'-四(2-吡啶甲基)乙二胺 CAS#: 16858-02-9

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N,N,N',N'-四(2-吡啶甲基)乙二胺

生物活性靶点体外研究 用途与合成方法 MSDS N,N,N',N'-四(2-吡啶甲基)乙二胺价格(试剂级) 上下游产品信息

中文名称	N,N,N',N'-四(2-吡啶甲基)乙二胺
中文同义词	N,N,N',N'-4(2-吡啶甲基)乙二胺;N,N,N',N'-四(2-吡啶甲基)乙二胺,室温保存即可;1,2-乙烷二胺, N,N,N',N'-四(2-吡啶基甲基)-;N,N,N',N'-四(2-吡啶甲基)乙二胺;N,N,N',N'-四(2-吡啶甲基)乙二胺;N,N,N',N'-四-(2-吡啶基甲基)乙二胺;N,N,N',N'-四KIS-(2-吡啶基甲基)乙二胺;N,N,N',N'-四-(2-吡啶基甲基)乙二
英文名称	TPEN
英文同义词	N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;TETRAKIS-(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;{2-[BIS(PYRIDIN-2-YLMETHYL)AMINO]ETHYL}BIS(PYRIDIN-2-YLMETHYL)AMINE;TPEN - CAS 16858-02-9 - Calbiochem;N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-Ethanediamine;CS-960;TPEN;1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-
CAS号	16858-02-9
分子式	C26H28N6
分子量	424.54
EINECS号
相关类别	杂环化合物;合成材料中间体;聚合试剂;其它;Apoptosis;Aromatics;Chelating Agents & Ligands;Heterocycles;Inhibitors;Apoptosis Inducers
Mol文件	16858-02-9.mol
结构式

N,N,N',N'-四(2-吡啶甲基)乙二胺 性质

N,N,N',N'-四(2-吡啶甲基)乙二胺 用途与合成方法

生物活性

TPEN (TPEDA) 是一种可透过细胞的重金属螯合剂，可通过负调控细胞内 NO 和 Zn2+ 信号转导来诱导NB4细胞凋亡。TPEN（TPEDA）可能是APL (acute promyelocytic leukemia) 的潜在治疗策略之一。

靶点

体外研究

Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. TPEN, a cell-permeable chelator for heavy metal cations with a low affinity for Ca     ²⁺    . In cells stimulated with 10 or 30 μM cadmium chloride, the addition of TPEN at 3 hr after exposure significantly decreases the elevated fura-2 fluorescence ratio to the basal levels within 10 min (119.6±2.4% or 109±1.5% decrease in ΔRatio (F340/F380) induced by 10 or 30 μM cadmium chloride, respectively), suggesting that a cadmium chloride-induced increase in the fura-2 fluorescence ratio is dependent on an increase in intracellular heavy metal cations but not intracellular Ca     ²⁺    . TPEN is a metal chelator, which targets colon cancer cells through redox cycling of copper. TPEN reduces cell viability in a dose- and time-dependent manner. TPEN-induced cell death is also dependent on the redox cycling of copper since the copper chelator neocuproine inhibited DNA damage and reduced pChk1, γ-H2AX, and ATM protein expression. Cell death by low TPEN concentrations, involved ATM/ATR signaling in all 3 cell lines, since pre-incubation with specific inhibitors of ATM and DNA-PK led to the recovery of cells from TPEN-induced DNA damage.

安全信息

MSDS信息

N,N,N',N'-四(2-吡啶甲基)乙二胺 价格(试剂级)

N,N,N',N'-四(2-吡啶甲基)乙二胺 上下游产品信息

上游原料

2,2-(二次氢基甲基茚己醇)二吡啶N,N'-BIS-2-PYRIDYLMETHYL ETHYLENEDIAMINE乙二胺2-氯甲基吡啶盐酸盐吡啶-2-甲醛