7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 CAS#: 440122-66-7

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7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇

生物活性靶点体内研究 用途与合成方法 MSDS 7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇价格(试剂级) 上下游产品信息

中文名称	7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇
中文同义词	7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇;化合物WAY 200070;WAY 200070,ERΒ激动剂
英文名称	7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
英文同义词	7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol;WAY 200070;7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol;WAY200070;WAY 200070;5-Benzoxazolol, 7-bromo-2-(4-hydroxyphenyl)-;7-Bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol;Estrogen Receptor/ERR,WAY200070,WAY-200070,Inhibitor,inhibit
CAS号	440122-66-7
分子式	C13H8BrNO3
分子量	306.11
EINECS号	604-604-1
相关类别
Mol文件	440122-66-7.mol
结构式

7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 性质

7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 用途与合成方法

生物活性

WAY-200070是选择性的雌激素受体激动剂，IC50值为2.3 nM。

靶点

IC50: 2.3 nM (ERRβ), 155 nM (ERRα)

体内研究

Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test.

安全信息

MSDS信息

7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 价格(试剂级)

7-溴-2-(4-羟基苯基)苯并[D]恶唑-5-醇 上下游产品信息