司替巴脒 CAS#: 122-06-5

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司替巴脒

生物活性靶点体外研究 用途与合成方法 MSDS 司替巴脒价格(试剂级) 上下游产品信息

中文名称	司替巴脒
中文同义词	司替巴脒;化合物 T13905
英文名称	stilbamidine
英文同义词	stilbamidine;4,4'-Stilbenedicarboxamidine;2-(2-phenylethenyl)benzenecarboximidamide;Ba 2652;Stilbamidin;Benzenecarboximidamide, 4,4'-(1,2-ethenediyl)bis-
CAS号	122-06-5
分子式	C16H16N4
分子量	264.33
EINECS号	2045195
相关类别
Mol文件	122-06-5.mol
结构式

司替巴脒 性质

司替巴脒 用途与合成方法

生物活性

Stilbamidine 是 Stilbene 衍生的二脒化合物，主要以其羟乙基磺酸盐形式发挥作用，用于抑制各种真菌感染。

靶点

fungal

体外研究

The high-affinity pentamidine transporter (HAPT1) is inhibited by Propamidine but displays only low affinity to Stilbamidine. adenosine-sensitive pentamidine transporter (ASPT1), in contrast, is strongly inhibited by Stilbamidine, and Propamidine. [     ³    H]pentamidine uptake is determined in the presence of various concentrations of adenosine (IC     ₅₀    =1.2 μM) or melarsen oxide (IC     ₅₀    =0.7 μM), as well as in the presence of 250 μM adenosine and increasing concentrations of hypoxanthine, Propamidine (IC     ₅₀    =6.1 μM) and Stilbamidine (IC     ₅₀    =110 μM). The two diamidine compounds, Stilbamidine and Pentamidine are used to treat in multiple myeloma, a disease in which increase of the globulin content of the serum is of frequent occurrence.

安全信息

MSDS信息

司替巴脒 价格(试剂级)

司替巴脒 上下游产品信息