毒胡萝卜素 CAS#: 67526-95-8

微信扫码

毒胡萝卜素

用途生物活性靶点体外研究体内研究 用途与合成方法 MSDS 毒胡萝卜素价格(试剂级) 上下游产品信息

中文名称	毒胡萝卜素
中文同义词	毒胡萝卜素(>95% (HPLC),BC);毒胡萝卜素, 来源于毒胡萝卜;毒萝卜素;毒胡萝卜素 5MG;化合物TTP 22;(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-乙酰氧基-4-(丁酰氧基)-3,3A-二羟基-3,6,9-三甲基-8-(((Z)-2-甲基丁-2-烯酰基)氧基)-2-氧代-2,3,3A,4,5,6,6A,7,8,9B-十氢薁并[4,5-B]呋喃-7-基辛酸酯;毒胡萝卜素(10 MM IN DMSO);毒胡萝卜素(10 MM IN DMSO)(进口)
英文名称	Thapsigargin
英文同义词	THAPSIGARGIN;Octanoic acid, (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]f uran-7-yl ester;(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate;Octanoic acid [(3S)-6α-acetoxy-2,3,3a,4,5,6,6aα,7,8,9bβ-decahydro-3β,3aα-dihydroxy-3,6,9-trimethyl-8β-[[(Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4β-(1-oxobutoxy)azuleno[4,5-b]furan]-7α-yl ester;Thapsigargin,97%;Octanoic Acid (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b- decahydro-3,3a-dihydroxy-3,6,9-triMethyl-8-[[(2Z)-2-Methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester;Octanoic Acid [3S-[3α,3aβ,4α,6β,6aβ,7β,8α(Z),9bα]]-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-triMethyl-8-[(2-Methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester;Thapsigargin (TG)
CAS号	67526-95-8
分子式	C34H50O12
分子量	650.75
EINECS号	614-076-3
相关类别	合成;生化试剂;抗生素;化合物;标准品;试剂盒-细胞分析试剂盒;对照品;plantgrowth;Adenosinetriphosphatase  (microsomal  calcium)Cell  Signaling  and  Neuroscience;Antitumor  Agents;Intracellular  Calcium  RegulatorsCancer  Research;Intracellular  Calcium  Signaling;Therapy  Adjuncts;A  to;Enzyme  Inhibitors  by  Enzyme;Calcium signaling;Signalling;Apoptosis;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件	67526-95-8.mol
结构式

毒胡萝卜素 性质

毒胡萝卜素 用途与合成方法

用途

毒胡萝卜素是广泛使用的肌细胞内质网Ca（2 +）-ATPases抑制剂。 它充当有效的，可渗透细胞的，不依赖IP3的细胞内钙释放剂，可阻止血管生成抑制素和内皮抑素诱导的细胞内Ca2 +的瞬时增加。 它通过破坏细胞内游离Ca2 +水平诱导细胞凋亡。

生物活性

Thapsigargin 是一种有效的、非竞争性的 the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) 的抑制剂，对carbachol诱导的[Ca2+]i瞬变在存不存在KCl预刺激条件下的IC50值分别为0.353 nM和0.448 nM。Thapsigargin 可诱导细胞凋亡。Thapsigargin 提取自植物Thapsia garganica。

靶点

体外研究

Thapsigargin (0.001- 1 μM; for 2 and 4 days) arrests cell proliferations in MH7A human rheumatoid arthritis synovial cells in a time- and dose-dependent manner.  
 Thapsigargin (0.001- 1 μM; for 2 and 4 days) induces cell apoptosis in MH7A cells in a time- and dose-dependent manner.  
 Thapsigargin (0.001- 1 μM; for 2 and 4 days) impairs mTOR activity and leads to cyclin D1 expressions in MH7A cells.  
 Thapsigargin inhibits Ca     ²⁺    entry into human neutrophil granulocytes.  
 Thapsigargin inhibits the carbachol-evoked [Ca     ²⁺    ]i-transients with (IC     ₅₀    =0.353 nM) or without (IC     ₅₀    =0.448 nM) a KCl-prestimulation, but an additional small component, with a much lower sensitivity (IC     ₅₀    =4814 nM), is observed in the absence of a KCl-prestimulation. In contrast, the KCl-evoked [Ca     ²⁺    ]i-transients displayed only one component with a very low sensitivity to Thapsigargin in both absence (IC     ₅₀    =3343 nM) and presence (IC     ₅₀    =6858 nM) of a carbachol-prestimulation.  

Cell Proliferation Assay

Apoptosis Analysis

Western Blot Analysis

体内研究

Thapsigargin (Injection; 0.25 ug/g, 0.5 ug/g and 1 ug/g; 24 hours) significant increases of 2 to 5-fold in chemokine and pro-inflammatory expression. Thapsigargin is more sensitive to inducing a systemic immune response.

安全信息

MSDS信息

毒胡萝卜素 价格(试剂级)

毒胡萝卜素 上下游产品信息