茯苓酸 CAS#: 29070-92-6

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茯苓酸

基本信息用途参考资料生物活性靶点体外研究体内研究 用途与合成方法 MSDS 茯苓酸价格(试剂级) 上下游产品信息

中文名称	茯苓酸
中文同义词	茯苓酸(标准品);茯灵酸;茯苓酸;茯苓酸(茯灵酸);茯苓酸?, BR;茯苓酸对照品,;AKT和ERK信号传导途径抑制剂(PACHYMIC ACID);标准品对照品】PACHYMIC ACID
英文名称	Pachymic acid
英文同义词	3-ACETYLTUMULOSIC ACID;Pachymic acid (3-O-Acetyltumulosic acid);PACHYMIC ACID;(3b,16a)-3-(Acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid;24-methylene-,(3β,16α)-;3-O-Acetyltumulosic acid;Lanost-8-en-21-oic acid, 3-(acetyloxy)-16-hydroxy-;3β-Acetyloxy-16α-hydroxy-24-methylenelanost-8-en-21-oic acid
CAS号	29070-92-6
分子式	C33H52O5
分子量	528.76
EINECS号
相关类别	中药对照品;标准品;植物提取物;对照品;植提标准品;标准品-对照品;细胞生物学试剂;标准品-中药标准品;标准品 -中药标准品;三萜;标准品，对照品;Natural metabolites;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol文件	29070-92-6.mol
结构式

茯苓酸 性质

茯苓酸 用途与合成方法

基本信息

外观与性状：白色粉末
闪点：184.7ºC
密度： 1.1 g/cm3
沸点：612.2ºC at 760 mmHg
折射率：1.539
蒸汽压：1.51E-17mmHg at 25°C

用途

茯苓酸是中药茯苓的特有成分,也是茯苓的主要活性成分之一,具有多种与药效有关的药理活性.目前茯苓酸已经引起广泛关注,对其研究越来越多,茯苓酸在抗肿瘤、抗炎、抗氧化、降血糖、镇静催眠等方面应用广泛。

参考资料

http://www.chemsrc.com/cas/54239-37-1_671704.html

生物活性

Pachymic acid 是一种来自 P. cocos 的三萜类化合物。Pachymic acid 抑制 Akt 和 ERK 信号传导途径。

靶点

体外研究

Pachymic acid (PA) is able to inhibit gallbladder cancer tumorigenesis involving affection of Akt and ERK signaling pathways. Pachymic acid (PA) treatment significantly inhibits Rho A, Akt and ERK pathway in gallbladder carcinoma cells. Pachymic acid (PA) treatment can dose-dependently downregulate PCNA, ICAM-1, RhoA, p-Akt and pERK. Cell growth is inhibited by 10 µg/mL Pachymic acid (PA) 12 h after treatment, and a concentration of 30 µg/mL further reduced cell growth. The growth of cells is suppressed in a time- and dose-dependent manner. After 48 h treatment, about 25%, 40% and 70% of the cell growth are inhibited by Pachymic acid (PA) at concentration of 10 µg/mL, 20 µg/mL and 30 µg/mL, respectively. Pachymic acid (PA) also inhibits the growth of gallbladder carcinoma cells in a time-dependent and dose-dependent manner.

体内研究

To evaluate the anti-tumor activity of Pachymic acid (PA) in vivo, human lung cancer NCI-H23 tumor xenograft models are used. Pachymic acid (PA) significantly suppresses tumor growth at doses of 30 and 60 mg/kg for 21 days compared with the control group.

化学性质 

易溶于吡啶 来源于多孔菌科Polyporaceae ,茯苓属Wolfiporias植物茯苓干燥的菌核

用途 

用于含量测定/鉴定/药理实验等
药理药效:对肝脏具细胞毒作用，能竞争性抑制磷脂酶A2（phospholipase A2，PLA2）的生物活性，降低PLA2介导的细胞损伤。

安全信息

MSDS信息

茯苓酸 价格(试剂级)

茯苓酸 上下游产品信息