吡咯烷二硫代甲酸铵盐 CAS#: 5108-96-3

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吡咯烷二硫代甲酸铵盐

用途生物活性靶点体外研究体内研究 用途与合成方法 MSDS 吡咯烷二硫代甲酸铵盐价格(试剂级) 上下游产品信息 专题

中文名称	吡咯烷二硫代甲酸铵盐
中文同义词	吡咯烷二硫代甲酸铵;四次甲基二硫代氨基甲酸铵;四亚甲基二硫代氨基甲酸铵;1-吡咯烷硫代羧酸铵盐/吡咯二硫代甲酸铵;1-吡咯烷羰基二硫酸铵盐;N-吡咯烷二硫代甲酸铵;1-吡咯烷硫代羧酸铵盐、吡咯二硫代甲酸铵、1-吡咯烷二硫代羧酸铵盐;吡咯烷二硫代甲酸铵盐
英文名称	Ammonium 1-pyrrolidinedithiocarbamate
英文同义词	1-Pyrrolidinecarbodithioic acid, ammonium salt,95%;Ammonium Pyrrolidine-N-dithiocarba;PDTC Pyrrolidinedithiocarbamate, ammonium derivative;Ammonium pyrrolidinedithiocarbamate,1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC;Ammonium pyrrolidine;1-Pyrrolidinecarbodithioic acid, aMMoniuM salt, 98% 25GR;Ammonium Pyrrolidine-N-dithiocarbamate 1-Pyrrolidinecarbodithioic Acid Ammonium Salt Pyrrolidine-N-dithiocarbamic Acid Ammonium Salt;PYRROLIDINE-1-DITHIOCARBOXYLIC ACID AMMO
CAS号	5108-96-3
分子式	C5H9NS2.H3N
分子量	164.3
EINECS号	225-834-4
相关类别	有机化工原料;生化试剂;酶抑制剂;细胞信号和神经生物学;细胞生物学试剂;化学试剂;化工原料;生化试剂-其他化学试剂;合成材料中间体-高分子材料;有机原料;医药中间体;细胞生物学;Nitric Oxide;标准品;格氏试剂;中药对照品;有机化工原料;通用生化试剂-有机酸
Mol文件	5108-96-3.mol
结构式

吡咯烷二硫代甲酸铵盐 性质

吡咯烷二硫代甲酸铵盐 用途与合成方法

用途

吡咯烷二硫代甲酸铵盐在包括金属螯合作用在内的生物化学应用中很有用。它被用来防止一氧化氮合酶的诱导。抑制白血病HL-60细胞的凋亡也是非常重要的。

生物活性

Pyrrolidinedithiocarbamate ammonium  (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC, Pyrrolidine dithiocarbamic acid ammonium salt)是NF-κB的有效抑制剂，抑制IκB磷酸化、阻止NF-κB易位入核并减少下游细胞因子的表达。

靶点

体外研究

Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production.  
 Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA.  
 Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells.

体内研究

The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis.

安全信息

MSDS信息

吡咯烷二硫代甲酸铵盐 价格(试剂级)

吡咯烷二硫代甲酸铵盐 上下游产品信息