α-雌二醇 CAS#: 57-91-0

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α-雌二醇

生物活性靶点体外研究体内研究 用途与合成方法 MSDS α-雌二醇价格(试剂级) 上下游产品信息 专题

中文名称	α-雌二醇
中文同义词	17-ALPHA-雌二醇;alpha-雌二醇;1,3,5(10)雌甾三烯-3,17Α-二醇;17Α-雌二醇;3,17Α-二羟基-1,3,5(10)雌甾三烯;表雌二醇;雌甾-1,3,5(10)三烯-3,17Α-二醇;炔雌醇杂质L(EP)
英文名称	Estradiol
英文同义词	1,3,5-estratriene-3,17-alpha-diol;1,3,5-Estratriene-3,17alpha-diol;17alpha-Oestradiol;3,17alpha-Dihydroxyestra-1,3,5(10)-triene;3,17-alpha-dihydroxyoestra-1,3,5(10)-triene;3,17alpha-Dihydroxyoestra-1,3,5(10)-triene;5(10)-triene-3,17-diol,(17-alpha)-estra-3;epiestradial
CAS号	57-91-0
分子式	C18H24O2
分子量	272.39
EINECS号	200-354-8
相关类别	抗生素、生物碱;甾体激素类;医药原料;医药原料药-科研原料;其它萜类;医药原材料;试剂盒-Elisa试剂盒;医用原料;化学试剂;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;APIs
Mol文件	57-91-0.mol
结构式

α-雌二醇 性质

α-雌二醇 用途与合成方法

生物活性

Alpha-Estradiol 是一种雌性激素，是 5α-reductase 抑制剂，有潜力用于雄原性脱发的研究。

靶点

体外研究

Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.

体内研究

Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.

用途 

治疗功能性子宫出血、原发性闭经、绝经期综合症等。

用途 

Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17α-stradiol and its selective receptor, ER-X, are not part of a cl assical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain.17-Estradiol may have enormous implications for hormone replac ement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer disease and ischemic stroke.

安全信息

MSDS信息

α-雌二醇 化学药品说明书

雌二醇|药典2005版雌二醇缓释贴片—雌二醇的测定—高效液相色谱法|药物分析方法信息

α-雌二醇 价格(试剂级)

α-雌二醇 上下游产品信息

上游原料

3-O-Methyl 17α-Estradiol17ALFA-双氢马烯雌酮

下游产品

对氨基苯甲醇雌酚酮3-O-Benzyl 17α-Estradiol