盐酸苯氟雷司 CAS#: 23642-66-2

微信扫码

盐酸苯氟雷司

生物活性靶点体外研究 用途与合成方法 MSDS 盐酸苯氟雷司价格(试剂级) 上下游产品信息

中文名称	盐酸苯氟雷司
中文同义词	盐酸苯氟雷司;N-(1-甲基-2-(3-[三氟甲基]-苯基)乙基]氨基乙醇苯甲酸酯;2-((1-(3-(三氟甲基)苯基)丙烷-2-基)氨基)乙基苯酸盐盐酸
英文名称	BENFLUOREX HYDROCHLORIDE
英文同义词	2-((1-methyl-2-(3-(trifluoromethyl)phenyl)ethyl)amino)-ethanobenzoate(est;2-((alpha-methyl-m-(trifluoromethyl)phenethyl)amino)-ethanobenzoate(est;2-((1-(3-(trifluoromethyl)phenyl)propan-2-yl)amino)ethyl benzoate hydrochloride;mediator;BENFLUOREX HYDROCHLORIDE;2-[[1-METHYL-2-[3-(TRIFLUOROMETHYL)-PHENYL]ETHYL]AMINO]ETHANOL BENZOATE (ESTER) HCL;2-[[1-METHYL-2[3-(TRIFLUOROMETHYL)-PHENYL]ETHYL]AMINO]ETHANOL BENZOATE ESTER HYDROCHLORIDE;2-((1-METHYL-2-[3-(TRIFLUOROMETHYL)PHENYL]ETHYL)AMINO)ETHYL BENZOATE HYDROCHLORIDE
CAS号	23642-66-2
分子式	C19H20F3NO2.ClH
分子量	387.82
EINECS号	245-801-8
相关类别	小分子抑制剂;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol文件	23642-66-2.mol
结构式

盐酸苯氟雷司 性质

盐酸苯氟雷司 用途与合成方法

生物活性

Benfluorex hydrochloride (JP-992 hydrochloride) 是一个肝核因子 4α (HNF4α) 激活剂。

靶点

HNF4α

体外研究

Benfluorex hydrochloride consistently activates insulin promoter activity as measured by an increased number of GFP-positive cells. Benfluorex hydrochloride increases the number of GFP-positive cells in a dose-responsive manner and increases the level of endogenous insulin mRNA. Consistent with being HNF4α activator, Benfluorex hydrochloride stimulates HNF4α expression. Benfluorex hydrochloride alters HNF4α protease sensitivity, while the inactive control compound does not. Benfluorex hydrochloride decreases, in a concentration-dependent manner, the synthesis of acid-soluble products and ketone bodies from oleate, whereas the production of     ¹⁴    CO     ₂    into citric acid cycle is markedly increased by Benfluorex hydrochloride. Benfluorex hydrochloride inhibits in a dose-dependent manner the rates of gluconeogenesis from lactate/pyruvate (10/1 nM).

安全信息

MSDS信息

盐酸苯氟雷司 价格(试剂级)

盐酸苯氟雷司 上下游产品信息

上游原料

苯甲酰氯