1-(2-噻唑基偶氮)-2-萘酚 CAS#: 1147-56-4

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1-(2-噻唑基偶氮)-2-萘酚

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 1-(2-噻唑基偶氮)-2-萘酚价格(试剂级) 上下游产品信息

中文名称	1-(2-噻唑基偶氮)-2-萘酚
中文同义词	1-(2-噻唑基偶氮)-2-萘酚;1-(2-噻唑偶氮)-2-萘酚;1-(2'-噻唑基偶氮)-2-萘酚;2-(2-羟基-1-萘基偶氮)噻唑;1-(2-联氮噻吩)-2-萘酚;1-(2’-噻唑偶氮)-2-萘酚;TAN[=1-(2-噻唑偶氮)-2-萘酚][过渡金属类用分光光度试剂];TAN[=1-(2-噻唑偶氮)-2-萘酚](>99.0%(T))
英文名称	1-(2-THIAZOLYLAZO)-2-NAPHTHOL
英文同义词	TAN;2-(2-Hydroxy-1-naphthylazo)thiazole,  TAN;Nitrilotantalum(III);1-(Thiazole-2-ylazo)-2-naphthol;1-(Thiazole-2-ylazo)naphthalene-2-ol;1-[(Thiazole-2-yl)azo]-2-naphthol;TAN  [=1-(2-Thiazolylazo)-2-naphthol];TAN [=1-(2-Thiazolylazo)-2-naphthol] [Spectrophotometric reagent for transition metals]
CAS号	1147-56-4
分子式	C13H9N3OS
分子量	255.3
EINECS号	214-555-3
相关类别	试剂和补充物;Analytical Chemistry;Azo Compounds;Chelating Reagents;Naphthylazo Compounds
Mol文件	1147-56-4.mol
结构式

1-(2-噻唑基偶氮)-2-萘酚 性质

1-(2-噻唑基偶氮)-2-萘酚 用途与合成方法

生物活性

NSC139021 (ERGi-USU) 是ERG阳性癌细胞生长的高度选择性抑制剂，抑制不同细胞系的 IC50 值为 30 到400 nM。

靶点

IC50: 30 to 400 nM (ERG-positive cancer cells)

体外研究

NSC139021 selectively inhibits growth of ERGpositive cancer cell lines with minimal effect on normal prostate or endothelial cells or ERG-negative tumor cell lines. The IC     ₅₀    of NSC139021 for cell growth inhibition of responsive cell lines range between 30 nM to 400 nM. Combination of NSC139021 with enzalutamide shows additive effects in inhibiting growth of VCaP cells. A screen of kinases reveal that NSC139021 directly bound the ribosomal biogenesis regulator atypical kinase RIOK2 and induces ribosomal stress signature.

体内研究

NSC139021 treatment inhibits growth of ERG-positive VCaP tumor xenografts with no apparent toxicity. Significant (P<0.05, P<0.005) inhibition of tumor growth is noted at day 26 in treatment groups indicating 44% (100 mg/kg) and 65% (150 mg/kg) reduction of tumor burden. At 100 mg/kg and 150 mg/kg, no apparent toxicity including weight loss, lethargy, diarrhea, loss of appetite, respiratory distress, or overall drug related toxicity is observed. .

安全信息

MSDS信息

1-(2-噻唑基偶氮)-2-萘酚 价格(试剂级)

1-(2-噻唑基偶氮)-2-萘酚 上下游产品信息