那可汀 CAS#: 128-62-1

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那可汀

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 那可汀价格(试剂级) 上下游产品信息 专题

中文名称	那可汀
中文同义词	那可汀;(S,R)-诺司卡品;诺司卡品;诺斯卡品;(S,R)-那可汀;纳可丁;那可汀[鹼];那可丁 USP标准品
英文名称	Narcotine
英文同义词	,2,3,4-tetrahydroisoquinaline;[S-(R*,S*)]-6,7-Dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-Isobenzofuranone;1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-;1-alpha-Narcotine;5-g)isoquinolin-5-yl)-,(s-(r*,s*))-3-dioxolo(4;5-g]isoquinolin-5-yl)-,[s-(theta,s)]-3-dioxolo[4;6,7-Dimethoxy-3-(4-methoxy-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-2-benzofuran-1(3H)-one;nsc5366
CAS号	128-62-1
分子式	C22H23NO7
分子量	413.42
EINECS号	204-899-2
相关类别	镇咳药物;标准品;化工原料;医药原料药;Intermediates & Fine Chemicals;Pharmaceuticals;Asymmetric  Synthesis;Chiral  Building  Blocks;Complex  Molecules;FINACEAE
Mol文件	128-62-1.mol
结构式

那可汀 性质

那可汀 用途与合成方法

生物活性

Noscapine ((S,R)-Noscapine) 是一种具有口服活性的苯酞异喹啉生物碱，具有强效镇咳作用。Noscapine 通过激活 sigma 阿片类受体 (sigma opioid receptors) 发挥镇咳作用，是一种非竞争性 Bradykinin 抑制剂。Noscapine 破坏微管动力学，诱导细胞有丝分裂停滞和凋亡 (apoptosis) 以及活性。Noscapine 具有抗癌，神经保护，抗炎活性，并且可以穿越血脑屏障。

靶点

Sigma opioid receptorsBradykininApoptosis

体外研究

Noscapine (0-1000 μM; 0-96 hours; rat C6 glioma cells) treatment inhibits cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. Noscapine inhibits the viability of rat C6 glioma cells with an IC     ₅₀    of 250 μM at 72 hours.  
 Noscapine exposure causes abnormal S-phase reentry, increases mitotic arrest and results in excessive DNA accumulation.  
 Cylindromatosis increases the ability of noscapine to induce mitotic arrest and apoptosis. Cylindromatosis enhances the effect of noscapine on microtubule polymerization and promotes noscapine binding to microtubules.

Cell Viability Assay

体内研究

Noscapine (300 mg/kg; oral gavage; daily; for 15 days; athymic female mice) treatment reduces tumor growth in mice.

化学性质 

无色结晶性粉末或有光泽的棱柱状或片状结晶；无臭，无味。几乎不溶于水，微溶于乙醇与乙醚，溶于氯仿。

用途 

支气管解痉性镇咳药。

安全信息

MSDS信息

那可汀 价格(试剂级)

那可汀 上下游产品信息

上游原料

7-O-DeMethyl α-Narcotine

下游产品

5,6,7,8-四氢-4-甲氧基-6-甲基-1,3-1,3-二氧杂环戊基(4,5-G)异喹啉-5-醇[S-(R*,S*)]-3,4-dimethoxy-alpha1-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-o-xylene-alpha,alpha'-diol