甲磺酸双氢麦角汀 CAS#: 24730-10-7

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甲磺酸双氢麦角汀

生物活性体外研究 用途与合成方法 MSDS 甲磺酸双氢麦角汀价格(试剂级) 上下游产品信息

中文名称	甲磺酸双氢麦角汀
中文同义词	甲磺酸双氢麦角汀;甲磺酰双氢麦角克碱;二氢麦角碱(甲磺酸盐);二氢麦角亭甲烷硫酸盐;双氢麦角汀 甲磺酸盐;甲磺酸双氢麦角汀 EP标准品;二氢麦角新碱甲磺酸盐;甲磺酸二氢麦角新碱
英文名称	DIHYDROERGOCRISTINE MESYLATE
英文同义词	(5’-alpha,10-alpha)-nylmethyl)monomethanesulfonate(salt);(5'alpha, 10alpha)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trione mesylate;C13168;(5'α,10α)-9,10-Dihydro-12'-hydroxy-2'-(1-methylethyl)-5'-(phenylmethyl)-ergotaman-3',6',18-trionemesylate;9,10-dihydro-ergocristinmonomethanesulfonate(salt);dihydroergocristinmesilat;ergotamane-3’,6’,18-trione,9,10-dihydro-12’-hydroxy-2’-(1-methylethyl)-5’-(phe;5'alpha-benzyl-9,10alpha-dihydro-12'-hydroxy-2'-isopropylergotaman-3',6',18-trione monomethanesulphonate
CAS号	24730-10-7
分子式	C36H45N5O8S
分子量	707.84
EINECS号	246-434-6
相关类别	化工原料;Organics;DID  -  DINDrugs  of  Abuse;ErgotamineForensic  and  Veterinary  Standards;AlkaloidsAlphabetic;Chemical  Structure;D;Drugs  of  Abuse;Drugs&Metabolites;Neat  Compounds;Serotonin receptor
Mol文件	24730-10-7.mol
结构式

甲磺酸双氢麦角汀 性质

甲磺酸双氢麦角汀 用途与合成方法

生物活性

Dihydroergocristine mesylate (DHEC mesylate) 是γ-secretase (GSI) 的抑制剂, 可减少阿尔茨海默氏病淀粉样蛋白 β 肽 (amyloid-β) 的产生, 与 γ-secretase 和 Nicastrin 结合的平衡解离常数 (Kd) 值分别为 25.7 nM 和 9.8 μM。

体外研究

Dihydroergocristine (DHEC) (2-20 μM; 24 hours) has an IC     ₅₀    value of 25 μM for inhibiting the activity of γ-secretase in T100 cells without affecting cell viability. Dihydroergocristine (2-20 μM; 24 hours) inhibits cellular Aβ production and causes a dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs) in HEK293 and decreases γ-secretase activity in fibroblast cells.

Western Blot Analysis

安全信息

MSDS信息

甲磺酸双氢麦角汀 价格(试剂级)

甲磺酸双氢麦角汀 上下游产品信息