羟基伊曲康唑(伊曲康唑代谢物) CAS#: 112559-91-8

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羟基伊曲康唑(伊曲康唑代谢物)

生物活性靶点体外研究体内研究 用途与合成方法 MSDS 羟基伊曲康唑(伊曲康唑代谢物)价格(试剂级) 上下游产品信息

中文名称	羟基伊曲康唑(伊曲康唑代谢物)
中文同义词	伊曲康唑杂质1;依曲康唑杂质;伊曲康唑代谢物;伊曲康唑2-羟基代谢物;羟基伊曲康唑;羟基伊曲康唑(伊曲康唑代谢物);伊曲康唑杂质8;2H6]-羟基曲康唑
英文名称	HYDROXY ITRACONAZOLE
英文同义词	HYDROXY ITRACONAZOLE;3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-;4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one;R 63373;Itraconazole Impurity 8(Hydroxy Itraconazole);4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)-;Itraconazole 2-Hydroxy Metabolite;Itraconazole metabolite Hydroxy Itraconazole
CAS号	112559-91-8
分子式	C35H38Cl2N8O5
分子量	721.63
EINECS号
相关类别	对照品-杂质对照品;临床检测标准物质;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Various Metabolites and Impurities;Isotooe labelled metabolites;metabolites;Isotopically Labeled Pharmaceutical Reference Standard
Mol文件	112559-91-8.mol
结构式

羟基伊曲康唑(伊曲康唑代谢物) 性质

羟基伊曲康唑(伊曲康唑代谢物) 用途与合成方法

生物活性

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) 是 Itraconazole (ITZ) 的活性代谢物，Itraconazole 是一种三唑类抗真菌剂。

靶点

Antifungal

体外研究

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ). Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration.

体内研究

The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view.

安全信息

MSDS信息

羟基伊曲康唑(伊曲康唑代谢物) 价格(试剂级)

羟基伊曲康唑(伊曲康唑代谢物) 上下游产品信息