(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE CAS#: 1395084-

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(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE

生物活性靶点体外研究 用途与合成方法 MSDS (E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE价格(试剂级) 上下游产品信息

中文名称	(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE
中文同义词	4-[(1E)-2-(2-氨基-4-羟基-5-甲基苯基)偶氮]-N-2-吡啶基苯磺酰胺;BROMODOMAIN抑制剂(MS436);化合物MS436;5-二甲氧基-4-羟基肉桂醛;(E)-4-((2-氨基-4-羟基-5-甲基苯基)二氮烯基)-N-(吡啶-2-基)苯磺酰胺;MS 436,BRD4(1)抑制剂;MS436游离态
英文名称	MS436
英文同义词	(E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide;MS-436; MS 436;4-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-N-pyridin-2-ylbenzenesulfonamide;CS-1882;MS436(95%);4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide;4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide                     MS436;MS436                                                             4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
CAS号	1395084-25-9
分子式	C18H17N5O3S
分子量	383.42
EINECS号
相关类别	小分子抑制剂;小分子抑制剂，天然产物;细胞生物学试剂;活性小分子库;Inhibitors
Mol文件	1395084-25-9.mol
结构式

(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE 性质

(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE 用途与合成方法

生物活性

MS436 是一种 bromodomain 抑制剂，有效作用于 BRD4 BrD1，Ki 为 30-50 nM，比作用于 BrD2 选择性高 10 倍。

靶点

Ki: 30-50 nM (BRD4 bromodomain)

体外研究

MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated K     _i    of 30-50 nM) with preference for the first bromodomain over the second. MS436 effectively inhibits BRD4 activity in NF-κB-directed production of NO and pro-inflammatory cytokine interleukin-6 in murine macrophages. MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression. MS436 exhibits potent affinity of an estimated K     _i    =30-50 nM for the BRD4 BrD1 and a 10-fold selectivity over the BrD2, which is achieved through a unique set of water-mediated intermolecular interactions.

安全信息

MSDS信息

(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE 价格(试剂级)

(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE 上下游产品信息