SCR7 CAS#: 1533426-72-0

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SCR7

生物活性体外研究体内研究 用途与合成方法 MSDS SCR7价格(试剂级) 上下游产品信息

中文名称	SCR7
中文同义词	2,3-二氢-5,6-二[(E)-(苯基亚甲基)氨基]-2-硫代-4(1H)-嘧啶酮
英文名称	SCR7
英文同义词	2,3-Dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone;5,6-bis((E)-benzylideneamino)-2-mercaptopyrimidin-4-ol;5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;SCR7;CS-1733;4(1H)-Pyrimidinone, 2,3-dihydro-5,6-bis[(E)-(phenylmethylene)amino]-2-thioxo-;SCR7 USP/EP/BP;5,6-bis[(E)-(phenylmethylidene)amino]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one
CAS号	1533426-72-0
分子式	C18H14N4OS
分子量	334.39
EINECS号
相关类别	小分子抑制剂，天然产物;抑制剂;小分子抑制剂;标准品;Inhibitors
Mol文件	1533426-72-0.mol
结构式

SCR7 性质

SCR7 用途与合成方法

生物活性

SCR7 是一种特异性 DNA Ligase IV 抑制剂，其阻断非同源性末端连接(NHEJ)。

体外研究

SCR7 effectively inhibits the formation of multimers at 200 μM and above. SCR7 successfully inhibits cell proliferation of MCF7, A549, HeLa, T47D, A2780, HT1080, and Nalm6 with IC50 of 40, 34, 44, 8.5, 120, 10, and 50 μM, respectively. SCR7 suppresses the NHEJ repair of CRISPR-Cas9-induced DSBs.

体内研究

SCR7 treatment (10 mg/kg, i.m.) significantly reduces breast adenocarcinoma-induced tumor, and exhibits 4-fold increase in lifespan compared with control group. However, in Swiss albino mice with Dalton’s lymphoma tumor model, SCR7 (20 mg/kg, i.p.) exhibits neither tumor regression nor increase in lifespan. In BALB/c mice, SCR7 (20 mg/kg, i.p.) significantly enhances the cytotoxic effects of radiation, etoposide and 3-Aminobenzamide on tumor derived from Dalton’s lymphoma (DLA) cells.

安全信息

MSDS信息

SCR7 价格(试剂级)

SCR7 上下游产品信息